Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31722782 | 0.74 | ECE1 (0.40) | ECE1ADORA2AADORA1CYP1A2PDPK1 | |
| SCHEMBL23701644 | 0.73 | ADORA2A (0.44) | ECE1ADORA2AADORA1PDPK1ALDH1A1 | |
| SCHEMBL12320484 | 0.73 | ADORA2A (0.41) | ECE1ADORA2AADORA1PDPK1SMPD3 | |
| SCHEMBL17793760 | 0.72 | KDM4E (0.65) | ECE1CYP1A2PDPK1ALDH1A1KDM4E | |
| SCHEMBL23719294 | 0.70 | PIM1 (0.54) | ADORA2AADORA1CYP1A2CDK2GSK3B | |
| SCHEMBL12277372 | 0.69 | ADORA2A (0.43) | ECE1ADORA2AADORA1PDPK1SMPD3 | |
| SCHEMBL26643045 | 0.69 | ECE1 (0.44) | ECE1CYP1A2PDPK1ALDH1A1KDM4E | |
| SCHEMBL4859665 | 0.69 | ADORA2A (0.44) | ECE1ADORA2AADORA1PDPK1PTGDR2 | |
| SCHEMBL25353607 | 0.68 | PIN1 (0.49) | CYP1A2CCNE2CCNE1CDK2ALDH1A1 | |
| SCHEMBL415485 | 0.67 | KDM4E (0.55) | ACMSDALDH1A1KDM4ETP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197551-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Merck Sharp & Dohme Corp. (US) | 2010-06-23 | — | — | EP | claimed |
| WO-2009032249-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK & CO., INC. (US) | 2009-03-12 | — | — | WO | claimed |
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-20050215608-A1 | Bis-aryl thiazole derivatives | AMGEN INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2003002062-A2 | BIS-ARYL THIAZOLE DERIVATIVES | TULARIK INC. (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215608-A1 | Bis-aryl thiazole derivatives | FABP4, PC, TXNRD2 | ECE1 3199/4885ADORA2A 3169/4885ADORA1 4398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.