Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.51 |
| ▸ | ALKBH2 | Q6NS38 | 2/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | ALKBH1 | Q13686 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18320461 | 0.86 | ALDH1A1 (0.39) | EGLN1ALKBH2HPGDSAKR1C3ALKBH1 | |
| SCHEMBL19975395 | 0.79 | SCN9A (0.45) | ALDH1A1PPARGMAPK10KMT2ANPSR1 | |
| SCHEMBL2529820 | 0.77 | FFAR4 (0.39) | AKR1C3ALDH1A1PPARGMAPK10KMT2A | |
| SCHEMBL4896499 | 0.77 | SNCA (0.40) | EGLN1ALDH1A1PPARGMAPK10KMT2A | |
| SCHEMBL31517602 | 0.73 | ALDH1A1 (0.34) | AKR1C3ALDH1A1PPARGMAPK10KMT2A | |
| SCHEMBL16547534 | 0.73 | TDO2 (0.39) | ALDH1A1PPARGMAPK10KMT2ANPSR1 | |
| SCHEMBL26388653 | 0.73 | TDP1 (0.34) | ALDH1A1PPARGMAPK10KMT2ANPSR1 | |
| SCHEMBL12571589 | 0.73 | ALKBH2 (0.66) | EGLN1ALKBH2HPGDSALKBH1 | |
| SCHEMBL23228040 | 0.72 | ALDH1A1 (0.33) | ALDH1A1PPARGMAPK10KMT2ANPSR1 | |
| SCHEMBL19975267 | 0.72 | PDE10A (0.34) | ALDH1A1PPARGMAPK10KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197551-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Merck Sharp & Dohme Corp. (US) | 2010-06-23 | — | — | EP | claimed |
| WO-2009032249-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK & CO., INC. (US) | 2009-03-12 | — | — | WO | claimed |