Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | CASP1 | P29466 | 7/20 | 0.34 |
| ▸ | CASP7 | P55210 | 7/20 | 0.34 |
| ▸ | USP2 | O75604 | 6/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3776179 | 0.91 | MPO (0.39) | MPOALDH1A1CASP1CASP7USP2 | |
| SCHEMBL3781206 | 0.87 | CNR2 (0.36) | MPOALDH1A1CASP1CASP7USP2 | |
| SCHEMBL3713217 | 0.82 | KCNH3 (0.41) | POLBHTTCNR2 | |
| SCHEMBL3787119 | 0.82 | KCNH3 (0.39) | MPOALDH1A1CYP1A2HSD17B10MEN1 | |
| SCHEMBL3782046 | 0.79 | MPO (0.45) | MPOALDH1A1CYP1A2HSD17B10MEN1 | |
| SCHEMBL3706380 | 0.79 | KCNH3 (0.42) | CNR2 | |
| SCHEMBL3787051 | 0.77 | MEN1 (0.39) | CYP1A2MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3788039 | 0.77 | MAPT (0.44) | HSD17B10MEN1KMT2ATSHRLMNA | |
| SCHEMBL3782859 | 0.76 | KCNH3 (0.47) | CDK2 | |
| SCHEMBL3785711 | 0.74 | KCNH3 (0.43) | MPOALDH1A1CYP1A2HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |