Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3785711 | 0.94 | KCNH3 (0.43) | MAPTKCNH3KDM4EF2MAPK1 | |
| SCHEMBL3781206 | 0.89 | CNR2 (0.36) | MAPTCNR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3787119 | 0.88 | KCNH3 (0.39) | MAPTKCNH3KDM4EF2PTGS2 | |
| SCHEMBL3706380 | 0.85 | KCNH3 (0.42) | CNR2KCNH3 | |
| SCHEMBL3780333 | 0.83 | CNR2 (0.48) | MAPTCNR2KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL3782046 | 0.83 | MPO (0.45) | MAPTKCNH3ADORA2AKDM4EMAPK1 | |
| SCHEMBL3782999 | 0.82 | KCNH3 (0.41) | KCNH3SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL13286377 | 0.80 | CNR2 (0.51) | MAPTCNR2ADORA2AKDM4EMAPK1 | |
| SCHEMBL3778147 | 0.80 | CNR2 (0.42) | MAPTCNR2KDM4EF2MAPK1 | |
| SCHEMBL3783407 | 0.79 | CA1 (0.42) | MAPTPTGS2TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |