SCHEMBL378020

SCHEMBL378020

COc1cc(OC)c2c(=O)[nH]c(-c3ccc(N4CCNCC4)cc3)nc2c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 8/20 0.58
HDAC3 O15379 8/20 0.54
HDAC4 P56524 8/20 0.54
HDAC1 Q13547 8/20 0.54
HDAC7 Q8WUI4 8/20 0.54
HDAC2 Q92769 8/20 0.54
HDAC10 Q969S8 8/20 0.54
HDAC11 Q96DB2 8/20 0.54
HDAC8 Q9BY41 8/20 0.54
HDAC6 Q9UBN7 8/20 0.54
HDAC9 Q9UKV0 8/20 0.54
HDAC5 Q9UQL6 8/20 0.54
IL17A Q16552 1/20 0.52
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 2/20 0.52
MAPT P10636 2/20 0.52
BRD2 P25440 2/20 0.51
BRD1 O95696 1/20 0.51
PARP1 P09874 1/20 0.51
CSNK1A1 P48729 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30053496 1.00 BRD4 (0.58) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL377771 0.96 BRD4 (0.55) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL25270804 0.91 BRD4 (0.51) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL348652 0.90 BRD4 (0.58) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL348420 0.90 KDM4E (0.65) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL30053201 0.90 KDM4E (0.65) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL30458677 0.88 BRD4 (0.56) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL10279776 0.87 BRD4 (0.52) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL377776 0.87 BRD4 (0.52) BRD4HDAC3HDAC4HDAC1HDAC7
SCHEMBL377720 0.87 BRD4 (0.55) BRD4HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408454-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2024-07-24 EP claimed
WO-2023104155-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF 标新生物医药科技(上海)有限公司 2023-06-15 WO claimed
EP-3268007-B1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES RESVERLOGIX CORP (CA) 2022-11-09 EP claimed
CN-114984016-A Compositions and methods for treating complement-associated diseases 雷斯韦洛吉克斯公司 2022-09-02 CN claimed
US-20190091235-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES HEPALINK (HONG KONG) LIMITED (HK) 2019-03-28 US claimed
US-10131640-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2018-11-20 US claimed
US-10111885-B2 Compositions and therapeutic methods for the treatment of complement-associated diseases RESVERLOGIX CORP. (CA) 2018-10-30 US claimed
EP-3268007-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES Resverlogix Corp. (CA) 2018-01-17 EP claimed
WO-2016147053-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES RESVERLOGIX CORP. (CA) 2016-09-22 WO claimed
US-20160263126-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES HEPALINK (HONG KONG) LIMITED (HK) 2016-09-15 US claimed
US-20160137613-A1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2016-05-19 US claimed
WO-2013175281-A1 USE OF SUBSTITUTED 2-PHENYL-3H-QUINAZOLIN-4-ONES AND ANALOGS FOR INHIBITING BROMODOMAIN AND EXTRA TERMINAL DOMAIN (BET) PROTEINS RVX THERAPEUTICS INC. (CA) 2013-11-28 WO claimed
US-20130281399-A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION RVX THERAPEUTICS INC. (CA) 2013-10-24 US claimed
EP-2408454-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2012-01-25 EP claimed
WO-2010106436-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2010-09-23 WO claimed
EP-4678638-A1 NEW E3 UBIQUITIN LIGASE LIGAND, PROTEIN DEGRADATION AGENT AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-01-14 EP disclosed
EP-4446324-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2024-10-16 EP disclosed
EP-2408454-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2012-01-25 EP disclosed
WO-2010106436-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2010-09-23 WO disclosed
WO-2010106436-A2 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2010-09-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160137613-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 BRD4 700/4885HDAC3 1275/4885HDAC4 910/4885
US-20130281399-A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION PHKB, BAZ2A, EP300 BRD4 10/4885HDAC3 54/4885HDAC4 84/4885
US-10111885-B2 Compositions and therapeutic methods for the treatment of complement-associated diseases C5, CFH, C1QBP BRD4 3811/4885HDAC3 1711/4885HDAC4 2370/4885
US-10131640-B2 Anti-inflammatory agents VCAM1, ICAM1, IL6 BRD4 744/4885HDAC3 1263/4885HDAC4 981/4885
US-20160263126-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES C5, CFH, C1QBP BRD4 3811/4885HDAC3 1711/4885HDAC4 2370/4885
US-20190091235-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES C5, CFH, C1QBP BRD4 3811/4885HDAC3 1711/4885HDAC4 2370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.