SCHEMBL3780205

SCHEMBL3780205

[O-][S+](c1ccccc1)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.54
TSHR P16473 1/20 0.54
KIF11 P52732 4/20 0.52
TRPV6 Q9H1D0 2/20 0.44
OPRM1 P35372 1/20 0.42
OPRL1 P41146 1/20 0.42
BACE1 P56817 1/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
CYP19A1 P11511 1/20 0.38
ACP3 P15309 1/20 0.38
CYP1A1 P04798 1/20 0.36
MAOB P27338 1/20 0.36
CYP1B1 Q16678 1/20 0.36
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
ORAI1 Q96D31 1/20 0.35
ORAI2 Q96SN7 1/20 0.35
ORAI3 Q9BRQ5 1/20 0.35
MGLL Q99685 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3134248 0.91 ALDH1A1 (0.43) ALDH1A1TSHRKIF11TRPV6CES2
SCHEMBL7938378 0.83 PAX8 (0.41) ALDH1A1TSHRKIF11TRPV6RAB9A
SCHEMBL244792 0.82 ALDH1A1 (0.59) ALDH1A1TSHRKIF11TRPV6OPRM1
SCHEMBL3203731 0.82 ALDH1A1 (0.59) ALDH1A1TSHRKIF11TRPV6OPRM1
Hydrochloric Acid SCHEMBL10439842 0.81 SLC6A4 (0.44) ALDH1A1TSHRKIF11OPRM1OPRL1
SCHEMBL26437524 0.81 ALDH1A1 (0.42) ALDH1A1TSHRKIF11TRPV6CYP1A1
SCHEMBL7937298 0.81 KIF11 (0.59) ALDH1A1TSHRKIF11TRPV6CYP1A1
SCHEMBL12336893 0.81 TDP1 (0.35) ALDH1A1TSHR
Bromide SCHEMBL3137320 0.80 ALDH1A1 (0.56) ALDH1A1TSHRKIF11TRPV6OPRM1
Hydrochloric Acid SCHEMBL31079531 0.80 ALDH1A1 (0.56) ALDH1A1TSHRKIF11TRPV6OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118373784-B One-pot preparation method of 2-aryl benzoxazole and asymmetric sulfoxide 江苏师范大学 2024-09-03 CN disclosed
CN-118373784-A One-pot preparation method of 2-aryl benzoxazole and asymmetric sulfoxide 江苏师范大学 2024-07-23 CN disclosed
EP-2187893-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS Anacor Pharmaceuticals, Inc. (US) 2010-05-26 EP disclosed
WO-2009111676-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC (US) 2009-09-11 WO disclosed
EP-2044091-A2 COMPOUNDS FOR THE TREATMENT OF PERIODONTAL DISEASE Anacor Pharmaceuticals, Inc. (US) 2009-04-08 EP disclosed
EP-1988779-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS Anacor Pharmaceuticals, Inc. (US) 2008-11-12 EP disclosed
WO-2007146965-A2 COMPOUNDS FOR THE TREATMENT OF PERIODONTAL DISEASE ANACOR PHARMACEUTICALS, INC. (US) 2007-12-21 WO disclosed
WO-2007095638-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC. (US) 2007-08-23 WO disclosed