SCHEMBL3782096

SCHEMBL3782096

CC(C)CN(Cl)c1ncccc1C#N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 7/20 0.40
ALDH1A1 P00352 6/20 0.40
SMN1; SMN2 Q16637 4/20 0.40
NPC1 O15118 4/20 0.40
RAB9A P51151 4/20 0.40
POLB P06746 2/20 0.40
L3MBTL1 Q9Y468 3/20 0.39
CYP1A2 P05177 3/20 0.39
CYP2D6 P10635 3/20 0.39
CYP2C9 P11712 3/20 0.39
CYP2C19 P33261 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
KDM4E B2RXH2 3/20 0.38
GAA P10253 1/20 0.38
CYP3A4 P08684 2/20 0.37
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
NPSR1 Q6W5P4 2/20 0.34
CYP11B2 P19099 1/20 0.34
CASP3 P42574 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3783787 0.77 ALDH1A1 (0.40) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL6191221 0.73 HTT (0.45) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL5200518 0.72 KCNMA1 (0.47) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL12125020 0.71 HPGD (0.43) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL21614128 0.69 ALDH1A1 (0.39) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL16580958 0.68 HPGD (0.40) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL14228959 0.68 AGTR1 (0.54) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL2627822 0.68 HPGD (0.53) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL2565156 0.67 SLC6A2 (0.43) HPGDALDH1A1SMN1; SMN2POLBL3MBTL1
SCHEMBL14229200 0.67 AGTR1 (0.42) HPGDALDH1A1SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2187893-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS Anacor Pharmaceuticals, Inc. (US) 2010-05-26 EP disclosed
WO-2009111676-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC (US) 2009-09-11 WO disclosed