SCHEMBL378373

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL378576	0.89	ALDH1A1 (0.55)	LMNACHEK1HDAC6CHKACA2
	SCHEMBL378360	0.85	ALDH1A1 (0.61)	LMNACHEK1HDAC6CHKACA2
	SCHEMBL145235	0.83	PARP1 (0.49)	LMNAPARP1PARP2PARP3GRM2
	SCHEMBL12380564	0.83	KDM4E (0.52)	LMNACHEK1PARP1PARP2PARP3
	Hydrochloric Acid SCHEMBL347360	0.82	PARP1 (0.48)	LMNAPARP1PARP2PARP3GRM2
	SCHEMBL3081902	0.80	HTT (0.56)	LMNACHEK1PARP1PARP2PARP3
	SCHEMBL547278	0.80	LMNA (0.66)	LMNAHDAC6CHKACA2NCF1
	SCHEMBL27682017	0.78	CHEK1 (0.49)	LMNACHEK1PARP1PARP2PARP3
	SCHEMBL2906006	0.77	HDAC6 (0.68)	LMNACHEK1PARP1PARP2PARP3
	SCHEMBL16178546	0.77	LMNA (0.62)	LMNAHDAC6CHKACA2NCF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.