Fosfluconazole

Fosfluconazole

SCHEMBL378428

O=P(O)(O)OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 16/20 0.62
CYP2C9 P11712 12/20 0.62
CYP2C19 P33261 12/20 0.62
LMNA P02545 2/20 0.62
HSP90AA1 P07900 1/20 0.62
CYP19A1 P11511 1/20 0.62
CYP11B1 P15538 1/20 0.62
CYP11B2 P19099 1/20 0.62
ADRA1A P35348 1/20 0.62
CYP51A1 Q16850 1/20 0.62
CYP2B6 P20813 1/20 0.48
CYP3A5 P20815 1/20 0.48
CYP3A7 P24462 1/20 0.48
MAPK1 P28482 1/20 0.48
CYP3A43 Q9HB55 1/20 0.48
CYP46A1 Q9Y6A2 1/20 0.48
CYP1A2 P05177 6/20 0.48
CYP2D6 P10635 6/20 0.48
KCNH2 Q12809 3/20 0.44
FDPS P14324 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fosfluconazole SCHEMBL27638104 0.99 CYP3A4 (0.61) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fosfluconazole SCHEMBL27971502 0.99 CYP3A4 (0.61) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL14193097 0.91 CYP3A4 (0.60) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL14221883 0.89 CYP3A4 (0.58) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fosfluconazole SCHEMBL5450058 0.88 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL10296768 0.88 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL10066654 0.83 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL10034136 0.83 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL14193103 0.83 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL10034138 0.82 CYP3A4 (0.53) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 567 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4719384-A2 COMPOUNDS WITH ANTIFUNGAL PROPERTIES Trustees of Dartmouth College (US) 2026-04-08 EP claimed
WO-2024249290-A2 COMPOUNDS WITH ANTIFUNGAL PROPERTIES TRUSTEES OF DARTMOUTH COLLEGE (US) 2024-12-05 WO claimed
US-20240196882-A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES AL.CHI.MI.A. S.R.L. (IT) 2024-06-20 US claimed
US-20240172743-A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES AL.CHI.MI.A. S.R.L. (IT) 2024-05-30 US claimed
EP-4368020-A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PESERVING BIOOLOGICAL TISSUES AL.CHI.MI.A. S.r.l. (IT) 2024-05-15 EP claimed
EP-4368021-A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES AL.CHI.MI.A. S.r.l. (IT) 2024-05-15 EP claimed
CN-111171075-B Preparation method of fosfluconazole 北京四环生物制药有限公司 2022-07-12 CN claimed
WO-2022124342-A1 AGENT FOR CANCER THERAPY, AND SCREENING METHOD FOR ACTIVE INGREDIENT THEREOF 国立大学法人 岡山大学 2022-06-16 WO claimed
CN-113559264-A Methods of treating microbial infections including mastitis 罗达制药公司 2021-10-29 CN claimed
CN-113144197-A Method of treating topical microbial infections 罗达制药公司 2021-07-23 CN claimed
EP-1534721-B1 PROCESS FOR CONTROLLING THE HYDRATE MIX OF THE DISODIUM SALT OF FOSFLUCONAZOLE PFIZER LTD (GB) 2006-07-26 EP claimed
US-6977302-B2 Triazole derivatives useful in therapy AGOURON PHARMACEUTICALS, INC. (US) 2005-12-20 US claimed
EP-1534721-A1 PROCESS FOR CONTROLLING THE HYDRATE MIX OF A COMPOUND Pfizer Limited (GB) 2005-06-01 EP claimed
US-20040236105-A1 Triazole derivatives useful in therapy PFIZER, INC. 2004-11-25 US claimed
WO-2004007507-A1 PROCESS FOR CONTROLLING THE HYDRATE MIX OF A COMPOUND PFIZER LIMITED (GB) 2004-01-22 WO claimed
US-20040007689-A1 Process for controlling the hydrate mix of a compound PFIZER INC. 2004-01-15 US claimed
US-20030144250-A1 Triazole derivatives useful in therapy GREEN STUART (GB) 2003-07-31 US claimed
EP-0880533-B1 Triazole derivatives useful in therapy PFIZER RES & DEV (IE) 2002-06-12 EP claimed
EP-0880533-A1 TRIAZOLE DERIVATIVES USEFUL IN THERAPY Pfizer Research and Development Company, N.V./S.A. (IE) 1998-12-02 EP claimed
WO-1997028169-A1 TRIAZOLE DERIVATIVES USEFUL IN THERAPY PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) 1997-08-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030144250-A1 Triazole derivatives useful in therapy CYP51A1, THOP1, ERG28 CYP3A4 87/4885CYP2C9 301/4885CYP2C19 202/4885
US-20240196882-A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES CRYAB, CRYZ, CRYAA CYP3A4 4766/4885CYP2C9 4767/4885CYP2C19 4852/4885
US-20040236105-A1 Triazole derivatives useful in therapy CYP51A1, ERG28, THOP1 CYP3A4 42/4885CYP2C9 227/4885CYP2C19 140/4885
US-20240172743-A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES CRYAB, CRYZ, CRYAA CYP3A4 4616/4885CYP2C9 4703/4885CYP2C19 4772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.