Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 12/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794699 | 0.83 | TRPM8 (0.50) | TRPM8TRPV1OPRD1HTR2BCYP2D6 | |
| Hydrochloric Acid SCHEMBL3709812 | 0.82 | OPRD1 (0.42) | TRPM8TRPV1OPRD1HTR1AHTR7 | |
| SCHEMBL30538347 | 0.77 | OPRD1 (0.65) | TRPV1OPRD1HTR2BCYP2D6KCNH2 | |
| SCHEMBL12481110 | 0.77 | OPRD1 (0.65) | TRPV1OPRD1HTR2BCYP2D6KCNH2 | |
| SCHEMBL30538352 | 0.75 | HTR2C (0.44) | TRPM8OPRD1CYP2D6KCNH2 | |
| SCHEMBL3789581 | 0.71 | TRPM8 (0.53) | TRPM8TRPV1HTR2B | |
| SCHEMBL5723045 | 0.69 | ALDH1A1 (0.43) | TRPM8TRPV1HTR2B | |
| SCHEMBL28385331 | 0.69 | OPRD1 (0.55) | TRPV1OPRD1HTR2BCYP2D6KCNH2 | |
| SCHEMBL16314494 | 0.69 | TRPM8 (0.53) | TRPM8TRPV1 | |
| Trifluoroacetic Acid SCHEMBL3716225 | 0.69 | TRPM8 (0.51) | TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |