Sugi Predict

Sugi Predict / Compounds / SCHEMBL3786158

SCHEMBL3786158

SCHEMBL3786158

CC(C)c1cccc(Cl)c1N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 3/20 0.52
▸ CYP3A4 P08684 2/20 0.52
▸ CYP2D6 P10635 1/20 0.52
▸ NFKB1 P19838 1/20 0.52
▸ PNMT P11086 1/20 0.52
▸ LMNA P02545 3/20 0.50
▸ ALDH1A1 P00352 2/20 0.50
▸ GLA P06280 1/20 0.50
▸ GABRA1 P14867 3/20 0.44
▸ GABRG2 P18507 2/20 0.44
▸ GABRB3 P28472 2/20 0.44
▸ GABRB2 P47870 2/20 0.44
▸ TSHR P16473 2/20 0.44
▸ HPGD P15428 2/20 0.44
▸ FAAH O00519 1/20 0.44
▸ CA1 P00915 1/20 0.44
▸ CA2 P00918 1/20 0.44
▸ GABRB1 P18505 1/20 0.44
▸ PTGS1 P23219 1/20 0.44
▸ SLC6A2 P23975 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL27575665 0.98 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6NFKB1PNMT
Propane SCHEMBL27563521 0.94 CYP1A2 (0.47) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL23203567 0.87 CYP1A2 (0.48) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL30051168 0.86 CYP1A2 (0.52) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL1170186 0.86 CYP1A2 (0.52) CYP1A2CYP3A4CYP2D6NFKB1PNMT
Hydrochloric Acid SCHEMBL6552987 0.85 ALDH1A1 (0.50) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL25510340 0.84 PNMT (0.67) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL11505568 0.84 CYP1A2 (0.50) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL29737250 0.84 PNMT (0.67) CYP1A2CYP3A4CYP2D6NFKB1PNMT
SCHEMBL104314 0.83 GABRA1 (0.55) CYP1A2CYP3A4CYP2D6NFKB1PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators GENENTECH, INC. (US) 2026-05-05 — — US disclosed
US-20250381187-A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME AMGEN INC. (US) 2025-12-18 — — US disclosed
US-12440491-B2 KRAS G12C inhibitors and methods of using the same AMGEN INC. (US) 2025-10-14 — — US disclosed
US-20240239792-A1 MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF ASIA VISION LIMITED (CN) 2024-07-18 — — US disclosed
US-20240050430-A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME AMGEN INC. 2024-02-15 — — US disclosed
EP-3788038-B1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME AMGEN INC (US) 2023-10-11 — — EP disclosed
US-11766436-B2 KRAS G12C inhibitors and methods of using the same AMGEN INC. (US) 2023-09-26 — — US disclosed
CN-113248521-B K-RAS G12C inhibitor and preparation method and application thereof 上海和誉生物医药科技有限公司 2023-07-18 — — CN disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
CN-1814582-A One-step method for preparing N-alkyl aromatic amine from aromatic nitro substance ZHEJIANG POLYTECHNIQUE UNIV (CN) 2006-08-09 — — CN disclosed
EP-0511826-B1 Phosphosulfonate herbicides ROHM & HAAS (US) 1997-07-16 — — EP disclosed
US-5500405-A Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1996-03-19 — — US disclosed
US-5272128-A Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1993-12-21 — — US disclosed
EP-0511826-A2 Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1992-11-04 — — EP disclosed
US-4418209-A ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS WILLIAM H. RORER, INC. (US) 1983-11-29 — — US disclosed
US-4326075-A ANTIDIARRHEA AGENTS WILLIAM H. RORER, INC. (US) 1982-04-20 — — US disclosed
US-4203920-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-05-20 — — US disclosed
US-4147804-A ANTIARRHYTHMIA AGENTS WILLIAM H. RORER, INC. (US) 1979-04-03 — — US disclosed
US-4060635-A Amidinoureas for treating diarrhea WILLIAM H. RORER, INC. (US) 1977-11-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239792-A1 MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF BCL2, BCL2L2, BCL2L1 CYP1A2 3232/4885CYP3A4 4350/4885CYP2D6 4042/4885
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS NLRP3, NLRP1, PYCARD CYP1A2 2314/4885CYP3A4 1720/4885CYP2D6 3744/4885
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators NLRP3, NLRP1, PYCARD CYP1A2 1132/4885CYP3A4 1480/4885CYP2D6 3048/4885
US-20250381187-A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME KRAS, NRAS, HRAS CYP1A2 4727/4885CYP3A4 4739/4885CYP2D6 4615/4885
US-12440491-B2 KRAS G12C inhibitors and methods of using the same KRAS, NRAS, HRAS CYP1A2 4727/4885CYP3A4 4739/4885CYP2D6 4615/4885
US-20240050430-A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME KRAS, NRAS, HRAS CYP1A2 4727/4885CYP3A4 4739/4885CYP2D6 4615/4885
US-11766436-B2 KRAS G12C inhibitors and methods of using the same KRAS, NRAS, HRAS CYP1A2 4727/4885CYP3A4 4739/4885CYP2D6 4615/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.