SCHEMBL378627

SCHEMBL378627

Nc1ccc(C(F)(F)F)c(F)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 12/20 0.70
GAA P10253 2/20 0.58
TSHR P16473 2/20 0.58
GLA P06280 1/20 0.58
POLB P06746 1/20 0.58
KDM1A O60341 1/20 0.48
AR P10275 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
SRC P12931 1/20 0.42
HPGD P15428 1/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
KMT2A Q03164 1/20 0.42
ATM Q13315 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TLR9 Q9NR96 1/20 0.42
MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29487197 1.00 KIF11 (0.70) KIF11GAATSHRGLAPOLB
Trifluoroacetic Acid SCHEMBL29430690 0.87 KIF11 (0.56) KIF11GAATSHRGLAPOLB
Phenol SCHEMBL28187712 0.85 KIF11 (0.54) KIF11GAATSHRGLAPOLB
SCHEMBL3903103 0.85 KIF11 (0.69) KIF11GAATSHRGLAPOLB
SCHEMBL28412450 0.84 KIF11 (0.52) KIF11GAATSHRGLAPOLB
SCHEMBL3899619 0.83 KIF11 (1.00) KIF11CYP11B1CYP11B2
SCHEMBL298720 0.82 KIF11 (0.50) KIF11GAATSHRGLAPOLB
SCHEMBL31481037 0.82 KIF11 (0.50) KIF11GAATSHRGLAPOLB
SCHEMBL146397 0.81 GAA (0.64) KIF11GAATSHRGLAPOLB
SCHEMBL29422813 0.81 GAA (0.64) KIF11GAATSHRGLAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 582 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117712391-A Electrode catalyst, preparation method thereof, membrane electrode and fuel cell 苏州擎动动力科技有限公司 2024-03-15 CN claimed
EP-2398771-A2 HETEROCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR Boehringer Ingelheim International GmbH (DE) 2011-12-28 EP claimed
WO-2010096371-A2 HETEROCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-08-26 WO claimed
US-7129235-B2 Amides useful for treating pain ABBOTT LABORATORIES (US) 2006-10-31 US claimed
US-20050080095-A1 administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I ABBVIE INC. 2005-04-14 US claimed
WO-2026102082-A1 ALKYLPHENYL SUBSTITUTED COMPOUNDS, COMPOSITIONS AND METHODS OF USE DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-15 WO disclosed
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. (US) 2026-05-14 US disclosed
EP-4717266-A2 OCTAHYDRO FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS Corcept Therapeutics Incorporated (US) 2026-04-01 EP disclosed
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2026-03-05 US disclosed
US-12565582-B2 Resin composition and metal clad substrate ITEQ CORPORATION (TW) 2026-03-03 US disclosed
US-20260055057-A1 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR ANTAGONISTS AND USES THEREOF PFIZER INC. (US) 2026-02-26 US disclosed
WO-2026042018-A1 4-{4-[(1-{[4-(PROPAN-2-YL)PHENYL]CARBAMOYL)-D-PROLYL)AMINO]CYCLOHEXYL}BENZOIC ACID DERIVATIVES AS GIPR ANTAGONISTS FOR THE TREATMENT OF DIABETES PFIZER INC. (US) 2026-02-26 WO disclosed
EP-0315869-A2 3-Cyano-4-(2,4-difluor-3-phenyl)-pyrrole BAYER AG (DE) 1989-05-17 EP disclosed
US-4782091-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1988-11-01 US disclosed
US-4782090-A Benzoyl(thio)urea pesticides BAYER AKTIENGESELLSCHAFT (DE) 1988-11-01 US disclosed
EP-0268943-A1 Benzoyl(thio)ureas BAYER AG (DE) 1988-06-01 EP disclosed
EP-0268952-A1 Benzoyl(thio) ureas BAYER AG (DE) 1988-06-01 EP disclosed
US-4411912-A Insecticidal isovaleric acid esters ZOECON CORPORATION (US) 1983-10-25 US disclosed
US-4264775-A BY DIAZOTIZATION OF ANILINES, REACTING WITH A VINYL ESTER, AND REACTING WITH A SECONDARY AMINE ELI LILLY AND COMPANY (US) 1981-04-28 US disclosed
US-4243819-A Substituted amino acids ZOECON CORPORATION (US) 1981-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260055057-A1 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR ANTAGONISTS AND USES THEREOF GIPR, GLP1R, GPR119 KIF11 4015/4885GAA 1535/4885TSHR 24/4885
US-20050080095-A1 administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I TRPV1, OPRL1, TRPV6 KIF11 4581/4885GAA 2594/4885TSHR 397/4885
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF KRAS, NRAS, HRAS KIF11 1470/4885GAA 4548/4885TSHR 2091/4885
US-20260132119-A1 Alkylphenyl Substituted Compounds, Compositions and Methods of Use GIPR, MC2R, GRPR KIF11 4294/4885GAA 633/4885TSHR 37/4885
US-12565582-B2 Resin composition and metal clad substrate MLLT3, CES2, CYP4X1 KIF11 4196/4885GAA 2029/4885TSHR 2824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.