Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.37 |
| ▸ | FEN1 | P39748 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849847 | 0.88 | ALOX5AP (0.36) | ALOX5APFEN1L3MBTL1OPRM1OPRK1 | |
| SCHEMBL9307372 | 0.78 | ALOX5AP (0.52) | ALOX5APFEN1L3MBTL1ALDH1A1HTT | |
| Ether SCHEMBL8368264 | 0.72 | CASP1 (0.40) | L3MBTL1EDNRAPTGS2ALDH1A1EDNRB | |
| SCHEMBL15924800 | 0.70 | ALOX5AP (0.52) | ALOX5APFEN1OPRM1OPRK1PTGS2 | |
| SCHEMBL9306541 | 0.69 | ALOX5AP (0.57) | ALOX5APFEN1OPRM1OPRK1PTGS2 | |
| SCHEMBL27500425 | 0.69 | ALDH1A1 (0.38) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL2704655 | 0.67 | PSIP1 (0.50) | ALOX5APFEN1EDNRAPTGS2ALDH1A1 | |
| SCHEMBL10958463 | 0.67 | CASP1 (0.41) | ALOX5APFEN1L3MBTL1OPRM1OPRK1 | |
| SCHEMBL6698432 | 0.66 | ALOX5AP (0.58) | ALOX5APFEN1OPRM1OPRK1EDNRA | |
| SCHEMBL10782653 | 0.66 | ALOX5AP (0.44) | ALOX5APFEN1OPRM1OPRK1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114801-A1 | ORAL FORMULATIONS OF DIPHENYLSULFONAMIDE ENDOTHELIN AND ANGIOTENSIN II RECEPTOR AGONISTS TO TREAT ELEVATED BLOOD PRESSURE AND DIABETIC NEPHROPATHY | LIGAND PHARMACEUTICALS INC. (US) | 2010-10-07 | — | — | WO | disclosed |