SCHEMBL378895

SCHEMBL378895

c1cc2ccc3nccnc3c2cn1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 1/20 0.53
DYRK1A Q13627 1/20 0.53
MAPK10 P53779 9/20 0.46
LMNA P02545 1/20 0.41
CYP3A4 P08684 1/20 0.38
TNF P01375 1/20 0.38
KDM4E B2RXH2 4/20 0.36
HIPK2 Q9H2X6 1/20 0.36
POLB P06746 2/20 0.34
ALDH1A1 P00352 2/20 0.34
MEN1 O00255 1/20 0.34
USP2 O75604 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
HTT P42858 2/20 0.34
RAD52 P43351 1/20 0.34
GRM4 Q14833 1/20 0.34
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31643631 1.00 CLK1 (0.53) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL13859942 0.85 CLK1 (0.44) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL17917463 0.84 IMPDH2 (0.43) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL18099781 0.77 KDM4E (0.57) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL29568934 0.76 LMNA (0.58) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL1419171 0.76 LMNA (0.58) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL31398339 0.75 CYP3A4 (0.61) LMNACYP3A4KDM4EPOLBALDH1A1
SCHEMBL730579 0.75 CYP3A4 (0.61) LMNACYP3A4KDM4EPOLBALDH1A1
SCHEMBL672509 0.75 CLK1 (0.54) CLK1DYRK1AMAPK10LMNACYP3A4
SCHEMBL29569821 0.75 CLK1 (0.54) CLK1DYRK1AMAPK10LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260130859-A1 PALATABLE FORMULATIONS ELANCO US INC (US) 2026-05-14 US claimed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP claimed
US-12544336-B2 Palatable formulations ELANCO US INC. 2026-02-10 US claimed
US-20230372249-A1 PALATABLE FORMULATIONS ELANCO US INC. 2023-11-23 US claimed
CN-116744917-A Palatable formulations 礼蓝美国公司 2023-09-12 CN claimed
EP-4208157-A1 PALATABLE FORMULATIONS ELANCO US INC. (US) 2023-07-12 EP claimed
WO-2022051478-A1 PALATABLE FORMULATIONS ELANCO US INC. (US) 2022-03-10 WO claimed
US-20120255502-A1 PACKAGE AND METHOD OF MARKETING ALLEVA ANIMAL HEALTH LIMITED (NZ) 2012-10-11 US claimed
US-7550464-B2 Use of phosphodiesterase 4 inhibitors such as 8,9-dimethoxy-6-phenyl-1,3,4,6,11,11a-hexahydro-2H -pyrazino[1,2-b]isoquinoline for treating asthma, chronic obstructive pulmonary disease, atopic dermatitis, allergic rhinitis, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis MITSUBISHI TANBE PHARMA CORPORATION (JP) 2009-06-23 US claimed
EP-1424326-B1 FUSED-POLYCYCLIC COMPOUNDS MITSUBISHI TANABE PHARMA CORP (JP) 2008-05-28 EP claimed
US-20070010521-A1 Condensed polycyclic compounds TANABE SEIYAKU CO., LTD. 2007-01-11 US claimed
US-7153859-B2 Condensed polycyclic compounds TANABE SEIYAKU CO., LTD. (JP) 2006-12-26 US claimed
US-20040204418-A1 Fused-polycyclic compounds TANABE SEIYAKU CO., LTD. (JP) 2004-10-14 US claimed
EP-1424326-A1 FUSED-POLYCYCLIC COMPOUNDS TANABE SEIYAKU CO., LTD. (JP) 2004-06-02 EP claimed
US-20260130859-A1 PALATABLE FORMULATIONS ELANCO US INC (US) 2026-05-14 US disclosed
US-20260130859-A1 PALATABLE FORMULATIONS ELANCO US INC (US) 2026-05-14 US disclosed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP disclosed
US-4162319-A ANTHELMINTICS, PSYCHOTROPIC, CNS, HYPOGLYCOMIC AGENTS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1979-07-24 US disclosed
US-4120961-A ANTIHELMINTICS, CNS ACITVITY E. MERCK (DE) 1978-10-17 US disclosed
US-3993760-A 2-BENZOYL-4-OXO-1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO(2,1 -A)ISOQUINOLINE ISOMER MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260130859-A1 PALATABLE FORMULATIONS CYP3A7, PGC, THPO CLK1 384/4885DYRK1A 1692/4885MAPK10 4438/4885
US-20230372249-A1 PALATABLE FORMULATIONS THPO, APRT, PDE8A CLK1 3934/4885DYRK1A 3714/4885MAPK10 4209/4885
US-20070010521-A1 Condensed polycyclic compounds PDE4A, PDE4B, PDE3B CLK1 3526/4885DYRK1A 4658/4885MAPK10 1138/4885
US-12544336-B2 Palatable formulations TRHDE, TMPO, PGC CLK1 1257/4885DYRK1A 2064/4885MAPK10 3675/4885
US-20040204418-A1 Fused-polycyclic compounds PDE4A, PDE4B, PDE3B CLK1 3634/4885DYRK1A 4482/4885MAPK10 1343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.