Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29195725 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1KDM4ETP53THRB | |
| SCHEMBL24100464 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL6699180 | 0.85 | KDM4E (0.59) | SMN1; SMN2ALDH1A1KDM4ETP53THRB | |
| SCHEMBL7311864 | 0.85 | TP53 (0.55) | SMN1; SMN2ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL19306009 | 0.84 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL21674083 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL23045052 | 0.84 | POLB (0.56) | SMN1; SMN2ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL1479187 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL4827444 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14513124 | 0.82 | ALDH1A1 (0.77) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112441984-B | Benzimidazole-substituted phenyl n-butyramide-based compound and preparation method thereof | 上海特化医药科技有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-111925299-A | Continuous flow method for synthesizing 3-methyl-4-butyryl-5-nitrobenzoic acid methyl ester and reaction device thereof | 浙江金立源药业有限公司 | 2020-11-13 | — | — | CN | claimed |
| CN-103319415-B | Production process of 2-n-propyl-4-methyl-6 (1-methylbenzimidazole-2-yl) -benzimidazole | HAIMEN CITY CHEMGOO PHARMA CO LTD | 2015-04-29 | — | — | CN | claimed |
| CN-103319415-A | Production process of 2-n-propyl-4-methyl-6 (1-methylbenzimidazole-2-yl) -benzimidazole | HAIMEN CITY CHEMGOO PHARMA CO LTD | 2013-09-25 | — | — | CN | claimed |
| CN-1184194-C | Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide | BAYER AG (DE) | 2005-01-12 | — | — | CN | claimed |
| EP-1268400-B1 | METHOD FOR PRODUCING N-BUTYRYL-4-AMINO-3-METHYL-METHYL BENZOATE AND THE NOVEL COMPOUND N-(4-BROMINE-2-METHYLPHENYL)-BUTANAMIDE | BAYER CHEMICALS AG (DE) | 2004-08-11 | — | — | EP | claimed |
| US-20040030183-A1 | Method for producing N-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound N-(4-bromo-2-methylphenyl)butanamide | RODEFELD LARS (DE) | 2004-02-12 | — | — | US | claimed |
| US-6620962-B2 | Reacting toluidine and butyryl chloride; then bromination; using palladium catalyst | BAYER AKTIENGESELLSCHAFT (DE) | 2003-09-16 | — | — | US | claimed |
| CN-1419535-A | Process for producing N-butyryl-4-amino-3-methyl-benzoic acid methyl ester and novel compound N- (4-bromo-2-methylphenyl) butyramide | BAYER AG (DE) | 2003-05-21 | — | — | CN | claimed |
| US-20030065211-A1 | Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide | LANXESS DEUTSCHLAND GMBH (DE) | 2003-04-03 | — | — | US | claimed |
| CN-112441984-B | Benzimidazole-substituted phenyl n-butyramide-based compound and preparation method thereof | 上海特化医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2021037127-A1 | BENZIMIDAZOLE SUBSTITUTION-BASED PHENYL N-BUTYRAMIDE COMPOUND AND PREPARATION METHOD THEREFOR | 上海特化医药科技有限公司 | 2021-03-04 | — | — | WO | disclosed |
| CN-111925299-A | Continuous flow method for synthesizing 3-methyl-4-butyryl-5-nitrobenzoic acid methyl ester and reaction device thereof | 浙江金立源药业有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-103319415-B | Production process of 2-n-propyl-4-methyl-6 (1-methylbenzimidazole-2-yl) -benzimidazole | HAIMEN CITY CHEMGOO PHARMA CO LTD | 2015-04-29 | — | — | CN | disclosed |
| CN-103319415-A | Production process of 2-n-propyl-4-methyl-6 (1-methylbenzimidazole-2-yl) -benzimidazole | HAIMEN CITY CHEMGOO PHARMA CO LTD | 2013-09-25 | — | — | CN | disclosed |
| US-20030065211-A1 | Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide | LANXESS DEUTSCHLAND GMBH (DE) | 2003-04-03 | — | — | US | disclosed |
| US-20030065211-A1 | Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide | LANXESS DEUTSCHLAND GMBH (DE) | 2003-04-03 | — | — | US | disclosed |
| EP-1268400-A2 | METHOD FOR PRODUCING N-BUTYRYL-4-AMINO-3-METHYL-METHYL BENZOATE AND THE NOVEL COMPOUND N-(4-BROMINE-2-METHYLPHENYL)-BUTANAMIDE | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072690-A3 | METHOD FOR PRODUCING N-BUTYRYL-4-AMINO-3-METHYL-METHYL BENZOATE AND THE NOVEL COMPOUND N-(4-BROMINE-2-METHYLPHENYL)-BUTANAMIDE | BAYER AG (DE) | 2002-02-28 | — | — | WO | disclosed |
| WO-2001072690-A2 | METHOD FOR PRODUCING N-BUTYRYL-4-AMINO-3-METHYL-METHYL BENZOATE AND THE NOVEL COMPOUND N-(4-BROMINE-2-METHYLPHENYL)-BUTANAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065211-A1 | Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide | GABBR2, BBOX1, GABRB3 | SMN1; SMN2 2334/4885ALDH1A1 1000/4885KDM4E 98/4885 |
| US-20040030183-A1 | Method for producing N-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound N-(4-bromo-2-methylphenyl)butanamide | BRD4, GABRB3, GABBR2 | SMN1; SMN2 961/4885ALDH1A1 1636/4885KDM4E 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.