Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789703 | 0.89 | MAPK8 (0.38) | HPGDCDK8ACVR1MAPTLMNA | |
| SCHEMBL16642353 | 0.88 | CRHR1 (0.38) | KDM4EHPGDCRHR1CDK8ACVR1 | |
| SCHEMBL513119 | 0.86 | KDM4E (0.33) | KDM4EHPGDCRHR1CDK8ACVR1 | |
| SCHEMBL466412 | 0.83 | MAPT (0.36) | HPGDCRHR1CDK8ACVR1MAPT | |
| SCHEMBL15341124 | 0.81 | KDM4E (0.36) | KDM4EHPGDCRHR1MAPTLMNA | |
| SCHEMBL15344226 | 0.81 | KDM4E (0.38) | KDM4EHPGDCRHR1MAPTLMNA | |
| SCHEMBL919364 | 0.81 | MAPT (0.38) | HPGDCDK8ACVR1MAPTLMNA | |
| SCHEMBL17224756 | 0.81 | PIM3 (0.32) | KDM4EHPGDALDH1A1 | |
| SCHEMBL17224782 | 0.81 | ALDH1A1 (0.36) | KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL17224781 | 0.81 | CSNK2A2 (0.41) | MAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014031971-A1 | HERBICIDAL PYRIDAZINONES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-02-27 | — | — | WO | disclosed |
| US-20140024527-A1 | HERBICIDAL PYRAZINONES | E I DU DE NEMOURS AND COMPANY (US) | 2014-01-23 | — | — | US | disclosed |
| US-20140024527-A1 | HERBICIDAL PYRAZINONES | E I DU DE NEMOURS AND COMPANY (US) | 2014-01-23 | — | — | US | disclosed |
| WO-2012148622-A1 | HERBICIDAL PYRAZINONES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012033548-A2 | HERBICIDAL BIS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024527-A1 | HERBICIDAL PYRAZINONES | CYP1B1, CBR3, CYP1A1 | KDM4E 3220/4885HPGD 659/4885CRHR1 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.