Aminocaproic Acid

Aminocaproic Acid

SCHEMBL379308

C=C1N=C(c2ccccc2)OC1=O.NCCCCCC(=O)O

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PLATPLG

The experimentally established mechanism targets of Aminocaproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLG known ✓ P00747 1/20 0.44
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
THRB P10828 1/20 0.44
ALOX15 P16050 1/20 0.44
SLC6A2 P23975 1/20 0.44
RECQL P46063 1/20 0.44
SLC6A3 Q01959 1/20 0.44
KMT2A Q03164 1/20 0.44
CYP2D6 P10635 1/20 0.41
NFKB1 P19838 1/20 0.41
BLM P54132 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
MAPT P10636 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gamma-Aminobutyric Acid SCHEMBL2897912 0.95 KMT2A (0.41) ALDH1A1MEN1PLGLMNATHRB
SCHEMBL2714415 0.78 SMN1; SMN2 (0.50) ALDH1A1MEN1PLGLMNARECQL
SCHEMBL24534659 0.75 SMN1; SMN2 (0.47) ALDH1A1MEN1PLGLMNARECQL
Gamma-Aminobutyric Acid SCHEMBL5795191 0.71 HDAC3 (0.41) ALDH1A1MEN1PLGLMNATHRB
Naphthalene SCHEMBL6898872 0.70 LMNA (0.68) ALDH1A1MEN1PLGLMNATHRB
Sebacic Acid SCHEMBL27729682 0.68 HDAC3 (0.61) ALDH1A1MEN1PLGLMNATHRB
Biphenyl SCHEMBL3175348 0.68 HDAC3 (0.65) ALDH1A1LMNASLC6A3NFKB1NPSR1
Biphenyl SCHEMBL7642659 0.68 HDAC3 (0.65) ALDH1A1LMNASLC6A3NFKB1NPSR1
Sebacic Acid SCHEMBL3165598 0.68 HDAC3 (0.65) ALDH1A1LMNASLC6A3NFKB1NPSR1
Octanedioate SCHEMBL8026045 0.68 HDAC3 (0.65) ALDH1A1LMNASLC6A3NFKB1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120129710-A1 METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS MEDIMMUNE LIMITED (GB) 2012-05-24 US disclosed
EP-1754787-B1 Methods for producing members of specific binding pairs MEDIMMUNE LTD (GB) 2012-01-25 EP disclosed
US-20100317540-A1 METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS MEDICAL RESEARCH COUNCIL (GB) 2010-12-16 US disclosed
US-7732377-B2 Methods for producing members of specific binding pairs MEDICAL RESEARCH COUNCIL (GB) 2010-06-08 US disclosed
US-20100136660-A1 METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS MCCAFFERTY JOHN 2010-06-03 US disclosed
US-7723270-B1 Methods for producing members of specific binding pairs MEDICAL RESEARCH COUNCIL (GB) 2010-05-25 US disclosed
US-7662557-B2 comprises a filamentous bacteriophage particle displaying on its surface a binding molecule which has a binding domain able to bind target epitope or antigen; genetic engineering MEDICAL RESEARCH COUNCIL (GB) 2010-02-16 US disclosed
US-7635666-B1 Methods for producing members of specific binding pairs MEDICAL RESEARCH COUNCIL (GB) 2009-12-22 US disclosed
US-20090155810-A1 METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS MEDICAL RESEARCH COUNCIL (GB) 2009-06-18 US disclosed
EP-1847605-A2 Methods for producing members of specific binding pairs Cambridge Antibody Technology Limited (GB) 2007-10-24 EP disclosed
EP-0589877-B2 METHODS FOR PRODUCING FUNCTIONAL, SINGLE-CHAIN Fv ANTIBODY FRAGMENTS ON THE SURFACE OF BACTERIOPHAGE PARTICLES CAMBRIDGE ANTIBODY TECH (GB) 2005-10-26 EP disclosed
US-6916605-B1 Methods for producing members of specific binding pairs MEDICAL RESEARCH COUNCIL (GB) 2005-07-12 US disclosed
US-6806079-B1 BACTERIOPHAGES; USED TO PRODUCE MONOCLONAL ANTIBODIES HAVING A SPECIFICITY AGAINST A PARTICULAR EPITOPE; IMMUNIZATION; SCREENING MEDICAL RESEARCH COUNCIL (GB) 2004-10-19 US disclosed
US-20040157214-A1 Methods for producing members of specific binding pairs CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED 2004-08-12 US disclosed
US-20040157215-A1 Methods for producing members of specific binding pairs CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED 2004-08-12 US disclosed
US-6172197-B1 LIBRARY OF FILAMENTOUS BACTERIOPHAGE PARTICLES DISPLAYING ON THEIR SURFACE FUSION PROTEINS OF PREFERENTIAL BINDING PROTEINS; FOR USE AS EFFICIENT GENETIC ENGINEERING DIAGNOSTIC TOOLS MEDICAL RESEARCH COUNCIL (GB) 2001-01-09 US disclosed
US-5969108-A Methods for producing members of specific binding pairs MEDICAL RESEARCH COUNCIL (GB) 1999-10-19 US disclosed
EP-0844306-A1 Methods of producing members of specific binding pairs Cambridge Antibody Technology Limited (GB) 1998-05-27 EP disclosed
EP-0589877-B1 METHODS FOR PRODUCING FUNCTIONAL, SINGLE-CHAIN Fv ANTIBODY FRAGMENTS ON THE SURFACE OF BACTERIOPHAGE PARTICLES CAMBRIDGE ANTIBODY TECH (GB) 1996-11-13 EP disclosed
WO-1992001047-A1 METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 1992-01-23 WO disclosed