Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG known ✓ | P00747 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL28059378 | 0.87 | CYP1A2 (0.62) | LMNAALDH1A1SLC6A3NFKB1CYP2D6 | |
| Adipic Acid SCHEMBL28144623 | 0.85 | CYP1A2 (0.60) | LMNAALDH1A1SLC6A3NFKB1CYP2D6 | |
| 5-Aminovaleric Acid SCHEMBL11669034 | 0.85 | NFKB1 (0.89) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| Acridine SCHEMBL557520 | 0.85 | ALDH1A1 (0.53) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| Benzamide SCHEMBL14574628 | 0.83 | LMNA (0.61) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| Aminocaproic Acid SCHEMBL1000930 | 0.83 | LMNA (0.90) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| Aminocaproic Acid SCHEMBL4909921 | 0.83 | LMNA (0.90) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| Adipic Acid SCHEMBL10591067 | 0.82 | LMNA (1.00) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| 12-Aminododecanoic Acid SCHEMBL20767098 | 0.82 | LMNA (1.00) | LMNAALDH1A1THRBKMT2ASLC6A3 | |
| SCHEMBL2778601 | 0.82 | LMNA (1.00) | LMNAALDH1A1THRBKMT2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004318111-A | COLORED PHOTOSENSITIVE RESIN COMPOSITION | SUMITOMO CHEM CO LTD | 2004-11-11 | — | — | JP | disclosed |