Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RASGRP3 | Q8IV61 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353614 | 0.88 | ALDH1A1 (0.56) | ALDH1A1KDM4EIMPDH2MAPTERN1 | |
| SCHEMBL13537254 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EIMPDH2MAPTKMT2A | |
| SCHEMBL3352006 | 0.82 | MAPT (0.52) | ALDH1A1MAPTERN1L3MBTL1PTPN1 | |
| SCHEMBL6764463 | 0.80 | KMT2A (0.49) | ALDH1A1KDM4EMAPTERN1PTPN1 | |
| SCHEMBL3353763 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL18096563 | 0.78 | MAPT (0.53) | ALDH1A1MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL29027035 | 0.78 | MAPT (0.53) | MAPTL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL20507307 | 0.78 | MAPT (0.56) | ALDH1A1MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL27709706 | 0.77 | CDK2 (0.46) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL30995729 | 0.77 | ALDH1A1 (0.70) | ALDH1A1KDM4EIMPDH2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263933-A | Alpha-carboline derivative and synthesis method thereof | 湘潭大学 | 2023-12-22 | — | — | CN | claimed |
| WO-2024140595-A1 | TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 珂阑(上海)医药科技有限公司 | 2024-07-04 | — | — | WO | disclosed |
| CN-118255685-A | Tricyclic compound, pharmaceutical composition and application thereof | 珂阑(上海)医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| WO-2024083208-A1 | KIF18A PROTEIN INHIBITOR | 杭州邦顺制药有限公司 | 2024-04-25 | — | — | WO | disclosed |
| CN-117263933-A | Alpha-carboline derivative and synthesis method thereof | 湘潭大学 | 2023-12-22 | — | — | CN | disclosed |
| WO-2020012424-A1 | SUBSTITUTED (AZA)INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2020-01-16 | — | — | WO | disclosed |
| WO-2017153952-A1 | 5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-09-14 | — | — | WO | disclosed |
| US-9636341-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-05-02 | — | — | US | disclosed |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-03 | — | — | US | disclosed |
| US-9150543-B2 | Substituted indolyl alkyl amino derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N. V. (BE) | 2015-10-06 | — | — | US | disclosed |
| US-20110136841-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | VERDONCK MARC GUSTAAF CELINE | 2011-06-09 | — | — | US | disclosed |
| CN-1993353-B | Substituted indolyl alkylamino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV | 2010-12-01 | — | — | CN | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| US-20090124646-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-14 | — | — | US | disclosed |
| CN-1993353-A | Substituted indolyl alkylamino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | CN | disclosed |
| EP-1781639-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006010750-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-02-02 | — | — | WO | disclosed |
| EP-0680950-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0680950-A1 | PROPENONE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124646-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | ALDH1A1 641/4885KDM4E 85/4885IMPDH2 453/4885 |
| US-20110136841-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | ALDH1A1 641/4885KDM4E 85/4885IMPDH2 453/4885 |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | ALDH1A1 641/4885KDM4E 85/4885IMPDH2 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.