Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379545 | 0.88 | ALDH1A1 (0.59) | ALDH1A1IMPDH2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7834682 | 0.80 | KMT2A (0.49) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL3352477 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL23551238 | 0.78 | ALDH1A1 (0.45) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL1631009 | 0.78 | MAPT (0.45) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL31520666 | 0.78 | MAPT (0.45) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL2275824 | 0.77 | ALDH1A1 (0.66) | ALDH1A1IMPDH2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3355435 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL2031700 | 0.76 | MAPT (0.47) | ALDH1A1LMNAMAPTL3MBTL1CDK2 | |
| SCHEMBL3354480 | 0.75 | HTR7 (0.49) | ALDH1A1KMT2ASMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-0680950-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0680950-A1 | PROPENONE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-08 | — | — | EP | disclosed |