Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10800709 | 0.82 | ALDH1A1 (0.48) | ALDH1A1ERN1IDO1 | |
| SCHEMBL4421669 | 0.82 | ALDH1A1 (0.34) | ALDH1A1ERN1 | |
| SCHEMBL1438997 | 0.77 | ERN1 (0.57) | ALDH1A1ERN1IDO1 | |
| SCHEMBL30808235 | 0.77 | ERN1 (0.57) | ALDH1A1ERN1IDO1 | |
| SCHEMBL820295 | 0.76 | ALDH1A1 (0.52) | ALDH1A1ERN1 | |
| SCHEMBL29556567 | 0.76 | ALDH1A1 (0.52) | ALDH1A1ERN1 | |
| SCHEMBL22964718 | 0.74 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL21234806 | 0.73 | ERN1 (0.38) | ERN1 | |
| SCHEMBL9253034 | 0.73 | ALDH1A1 (0.48) | ALDH1A1 | |
| SCHEMBL21021741 | 0.73 | CYP3A4 (0.52) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902394-B2 | Calcilytic compounds | GLAXOSMITHKLINE LLC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20100029782-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
| EP-2120898-A1 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077009-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029782-A1 | Calcilytic Compounds | CALCR, CALCA, CALCB | ALDH1A1 3794/4885ERN1 2647/4885IDO1 4470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.