Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994 | 0.90 | L3MBTL1 (0.41) | CACNA2D1POLBTDP1SLC6A4TP53 | |
| SCHEMBL10155 | 0.90 | TRPM8 (0.42) | CACNA2D1POLBTDP1MAPTTP53 | |
| SCHEMBL10359727 | 0.87 | SLC7A5 (0.52) | CACNA2D1PPARGPPARASLC6A4LMNA | |
| SCHEMBL10451 | 0.82 | PPARG (0.39) | CACNA2D1POLBTDP1PPARGPPARA | |
| SCHEMBL9744 | 0.80 | SLC6A4 (0.49) | CACNA2D1SLC6A4LMNASLC6A2 | |
| SCHEMBL2014600 | 0.77 | SLC6A2 (0.61) | CACNA2D1SLC6A4SLC6A2 | |
| SCHEMBL3336 | 0.77 | SLC6A2 (0.61) | CACNA2D1SLC6A4SLC6A2 | |
| SCHEMBL4739366 | 0.76 | SLC6A9 (0.53) | PPARGPPARASLC6A4LMNATP53 | |
| SCHEMBL5869349 | 0.76 | SLC6A2 (0.44) | CACNA2D1SLC6A4SLC6A2 | |
| Oxalic Acid SCHEMBL3799 | 0.76 | SLC6A4 (0.58) | CACNA2D1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |