Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486 | 0.90 | TRPM8 (0.42) | SLC6A9POLBTDP1TRPM8SLC7A5 | |
| SCHEMBL10102 | 0.90 | ALDH1A1 (0.41) | SLC6A9POLBTDP1TRPM8SLC7A5 | |
| SCHEMBL10539 | 0.87 | SLC7A5 (0.52) | PPARGPPARASLC6A9TRPM8SLC7A5 | |
| SCHEMBL3800 | 0.82 | CACNA2D1 (0.39) | PPARGPPARAPOLBTDP1SLC7A5 | |
| SCHEMBL3700 | 0.80 | SLC6A4 (0.44) | LMNAKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL3312531 | 0.77 | SLC6A2 (0.56) | LMNAKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1535377 | 0.77 | SLC6A2 (0.56) | LMNAKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL2741 | 0.77 | SLC6A2 (0.56) | LMNAKDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL3568 | 0.76 | SLC6A4 (0.45) | LMNAKDM4EMEN1NPC1ALDH1A1 | |
| Oxalic Acid SCHEMBL10450 | 0.76 | SLC6A9 (0.48) | SLC6A9CACNA2D1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |