Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GYS1 | P13807 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800984 | 0.94 | GYS1 (0.41) | HTTGYS1THRATHRBMCHR1 | |
| SCHEMBL3806836 | 0.92 | KDM4E (0.41) | HTTGYS1THRATHRBMCHR1 | |
| SCHEMBL3802151 | 0.86 | TSHR (0.40) | LMNAL3MBTL1GYS1THRATHRB | |
| SCHEMBL3807594 | 0.86 | SLC6A9 (0.42) | HTTTHRATHRBHDAC4HDAC2 | |
| SCHEMBL3800631 | 0.85 | LMNA (0.38) | LMNAGYS1THRATHRBLPAR1 | |
| SCHEMBL3804919 | 0.84 | SLC6A9 (0.39) | HTTTHRATHRBLPAR1HDAC4 | |
| SCHEMBL3806790 | 0.83 | MEN1 (0.45) | TDP1L3MBTL1THRATHRBKDM4E | |
| SCHEMBL3804567 | 0.83 | CTSA (0.41) | GYS1THRATHRBMCHR1LPAR1 | |
| SCHEMBL3803403 | 0.83 | SLC6A9 (0.39) | HTTGYS1THRATHRBLPAR1 | |
| SCHEMBL3784791 | 0.82 | THRA (0.41) | LMNAHTTL3MBTL1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |