Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3780490 | 0.89 | THRB (0.45) | THRATHRBLMNAMEN1KMT2A | |
| SCHEMBL3710103 | 0.88 | THRB (0.50) | THRATHRBPTK2 | |
| SCHEMBL3800984 | 0.86 | GYS1 (0.41) | THRATHRBSLC6A9HTTKEAP1 | |
| SCHEMBL3806836 | 0.84 | KDM4E (0.41) | THRATHRBKDM4EPOLBSLC6A9 | |
| SCHEMBL3802151 | 0.84 | TSHR (0.40) | THRATHRBLMNAKMT2APOLB | |
| SCHEMBL3800631 | 0.83 | LMNA (0.38) | THRATHRBLMNAMEN1KMT2A | |
| SCHEMBL3800512 | 0.82 | LMNA (0.42) | THRATHRBLMNAALDH1A1KDM4E | |
| SCHEMBL3806790 | 0.81 | MEN1 (0.45) | THRATHRBMEN1KMT2AALDH1A1 | |
| SCHEMBL3800575 | 0.80 | KMT2A (0.43) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL3701595 | 0.79 | THRA (0.62) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |