Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 15/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801000 | 0.81 | RAB9A (0.52) | PKMALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL1221581 | 0.76 | PKM (0.63) | PKMALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL30754639 | 0.70 | PKM (0.67) | PKMALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL28819251 | 0.70 | PKM (0.67) | PKMALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL3801002 | 0.68 | ALDH1A1 (0.55) | PKMALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL17175752 | 0.67 | KMT2A (0.73) | PKMALDH1A1RAB9AKMT2A | |
| SCHEMBL28819252 | 0.67 | ALDH1A1 (0.76) | PKMALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL2890913 | 0.66 | PKM (0.70) | PKMALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL18711517 | 0.66 | PKM (0.73) | PKMALDH1A1RAB9AKMT2A | |
| SCHEMBL30530721 | 0.64 | PARP10 (0.49) | ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842696-B2 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-30 | — | — | US | claimed |