Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1566864 | 0.72 | CA12 (0.38) | ALDH1A1SMN1; SMN2TDP1EGFRCA12 | |
| SCHEMBL1121892 | 0.70 | ALOX15 (0.51) | ALDH1A1GAAMAPTMEN1RECQL | |
| SCHEMBL1320587 | 0.69 | ELANE (0.32) | ALDH1A1SMN1; SMN2TDP1EGFRCA12 | |
| SCHEMBL1316195 | 0.69 | PARP10 (0.41) | ALDH1A1GAAMAPTMEN1KMT2A | |
| SCHEMBL6017086 | 0.67 | ADRA1A (0.33) | ALDH1A1MAPTKMT2ASMN1; SMN2CA12 | |
| SCHEMBL2616107 | 0.67 | CYP3A4 (0.55) | ALDH1A1GAAMAPTMEN1RECQL | |
| SCHEMBL31656211 | 0.67 | CYP3A4 (0.55) | ALDH1A1GAAMAPTMEN1RECQL | |
| SCHEMBL29935746 | 0.66 | ALDH1A1 (0.65) | ALDH1A1GAAMAPTMEN1RECQL | |
| SCHEMBL29462465 | 0.66 | ALDH1A1 (0.65) | ALDH1A1GAAMAPTMEN1RECQL | |
| SCHEMBL335539 | 0.66 | ALDH1A1 (0.65) | ALDH1A1GAAMAPTMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122804-A1 | SUBSTITUTED QUINOBENZOXAZINE ANALOGS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20110065687-A1 | HYDRAZIDE COMPOUNDS AND USES THEREOF | SENHWA BIOSCIENCES, INC. (TW) | 2011-03-17 | — | — | US | disclosed |
| US-7612063-B2 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7507727-B2 | Substituted quinobenzoxazine analogs and methods of using thereof | CYLENE PHARMACEUTICALS, INC. (US) | 2009-03-24 | — | — | US | disclosed |
| WO-2008131134-A1 | HYDRAZIDE COMPOUNDS AND USES THEREOF | CYLENE PHARMACEUTICALS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080261963-A1 | SUBSTITUTED QUINOBENZOXAZINE ANALOGS | CYLENE PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| US-7381720-B2 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS, INC. (US) | 2008-06-03 | — | — | US | disclosed |
| US-7354916-B2 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS (US) | 2008-04-08 | — | — | US | disclosed |
| US-7326702-B2 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1773346-A1 | SUBSTITUTED QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | Cylene Pharmaceuticals, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20070043039-A1 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS, INC. | 2007-02-22 | — | — | US | disclosed |
| US-7141565-B1 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS, INC. (US) | 2006-11-28 | — | — | US | disclosed |
| US-20060229303-A1 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS, INC. | 2006-10-12 | — | — | US | disclosed |
| WO-2006078317-A1 | SUBSTITUTED QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS, INC. (US) | 2006-07-27 | — | — | WO | disclosed |
| US-20060029950-A1 | Substituted quinobenzoxazine analogs and methods of using thereof | CYLENE PHARMACEUTICALS, INC. | 2006-02-09 | — | — | US | disclosed |
| US-20050085468-A1 | Substituted quinobenzoxazine analogs | CYLENE PHARMACEUTICALS | 2005-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085468-A1 | Substituted quinobenzoxazine analogs | CYP3A5, UGT2B7, CYP2D6 | ALDH1A1 553/4885GAA 325/4885MAPT 3632/4885 |
| US-20060229303-A1 | Substituted quinobenzoxazine analogs | CYP3A5, UGT2B7, CYP2D6 | ALDH1A1 553/4885GAA 325/4885MAPT 3632/4885 |
| US-20080261963-A1 | SUBSTITUTED QUINOBENZOXAZINE ANALOGS | CYP3A5, UGT2B7, CYP2D6 | ALDH1A1 553/4885GAA 325/4885MAPT 3632/4885 |
| US-20120122804-A1 | SUBSTITUTED QUINOBENZOXAZINE ANALOGS | CYP3A5, UGT2B7, CYP2D6 | ALDH1A1 553/4885GAA 325/4885MAPT 3632/4885 |
| US-20070043039-A1 | Substituted quinobenzoxazine analogs | TP53, CCNY, ACIN1 | ALDH1A1 855/4885GAA 478/4885MAPT 4052/4885 |
| US-20110065687-A1 | HYDRAZIDE COMPOUNDS AND USES THEREOF | EIF2AK2, DDX21, POLI | ALDH1A1 3894/4885GAA 1553/4885MAPT 4070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.