Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15783782 | 0.84 | HDAC4 (0.44) | MAPTTSHRCYP3A4PPARGPPARD | |
| SCHEMBL15241086 | 0.80 | PKM (0.47) | MAPTTSHRCYP3A4PPARDNPSR1 | |
| SCHEMBL8115552 | 0.80 | MAPT (0.56) | MAPTCYP3A4L3MBTL1TUBB4ATUBB | |
| SCHEMBL1613430 | 0.78 | MGAM (0.41) | MAPTTSHRCYP3A4PPARGPPARD | |
| SCHEMBL15417892 | 0.78 | CNR2 (0.40) | MAPTTSHRCYP3A4PPARGPPARD | |
| SCHEMBL11983745 | 0.77 | CYP3A4 (0.56) | MAPTCYP3A4PDE3BPDE3A | |
| SCHEMBL31545189 | 0.75 | GABRA1 (0.44) | TSHRCYP3A4NPSR1GAABLM | |
| SCHEMBL27595576 | 0.75 | CNR2 (0.42) | MAPTTSHRNPSR1L3MBTL1KMT2A | |
| SCHEMBL11983792 | 0.75 | ALDH1A1 (0.48) | CYP3A4CYP1A2GAAPDE3BPDE3A | |
| SCHEMBL11436443 | 0.75 | ACHE (0.54) | CYP3A4GAAHDAC4HDAC8PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101434517-B | 1, 2-diphenylethylene derivatives for the treatment of immune disorders | BEIJING WENFENG TIANJI PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-08-27 | — | — | CN | disclosed |
| US-8487009-B2 | 1,2-diphenylethene derivatives for treatment of immune diseases | GLAXO GROUP LIMITED (GB) | 2013-07-16 | — | — | US | disclosed |
| EP-1368306-B1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | WELICHEM BIOTECH INC (CA) | 2013-01-16 | — | — | EP | disclosed |
| US-20090149548-A1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | WELICHEM BIOTECH, INC. (CA) | 2009-06-11 | — | — | US | disclosed |
| CN-101434517-A | 1, 2-diphenylethylene derivatives for the treatment of immune disorders | WELICHEM BIOTECH INC (CN) | 2009-05-20 | — | — | CN | disclosed |
| CN-100462354-C | 1, 2-diphenylethylene derivatives for the treatment of immune disorders | WELICHEM BIOTECH INC (CN) | 2009-02-18 | — | — | CN | disclosed |
| US-20040102517-A1 | Modulators of T- cells, neutrophils, macrophages and their associated cytokines | GLAXO GROUP LIMITED (GB) | 2004-05-27 | — | — | US | disclosed |
| CN-1455766-A | 1, 2-diphenylethylene derivatives for the treatment of immune disorders | WELICHEM BIOTECH INC (CA) | 2003-11-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149548-A1 | NOVEL 1,2-DIPHENYLETHENE DERIVATIVES FOR TREATMENT OF IMMUNE DISEASES | IL2, IFNG, NFATC1 | MAPT 1934/4885TSHR 2714/4885CYP3A4 2152/4885 |
| US-20040102517-A1 | Modulators of T- cells, neutrophils, macrophages and their associated cytokines | IL2, NFATC1, IFNG | MAPT 1655/4885TSHR 1631/4885CYP3A4 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.