Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.76 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.76 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolmetin SCHEMBL3150 | 0.86 | PTGS2 (1.00) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL12608965 | 0.86 | PTGS2 (0.78) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL11325188 | 0.86 | PTGS2 (1.00) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL9724249 | 0.85 | PTGS2 (0.76) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL29461 | 0.85 | PTGS2 (0.97) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL5980424 | 0.85 | PTGS2 (0.97) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL11486460 | 0.85 | PTGS2 (0.97) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL28562007 | 0.85 | PTGS2 (0.97) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL13653108 | 0.84 | PTGS2 (0.74) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL1477674 | 0.84 | HPGD (1.00) | PTGS2CXCL8AKR1B1PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353579-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO LTD (CN) | 2021-11-18 | — | — | US | disclosed |
| US-9872846-B2 | High penetration compositions and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2018-01-23 | — | — | US | disclosed |
| US-20170209585-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO LTD (CN) | 2017-07-27 | — | — | US | disclosed |
| US-20170209404-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2017-07-27 | — | — | US | disclosed |
| EP-2990402-A1 | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ARYL- AND HETEROARYLACETIC ACIDS WITH VERY FAST SKIN PENETRATION RATE | Techfields Biochem Co. Ltd (CN) | 2016-03-02 | — | — | EP | disclosed |
| EP-2049482-B1 | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ARYL- AND HETEROARYLACETIC ACIDS WITH VERY FAST SKIN PENETRATION RATE | TECHFIELDS BIOCHEM CO LTD (CN) | 2015-10-21 | — | — | EP | disclosed |
| US-20090238763-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO., LTD. (CN) | 2009-09-24 | — | — | US | disclosed |
| EP-2049482-A1 | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ARYL- AND HETEROARYLACETIC ACIDS WITH VERY FAST SKIN PENETRATION RATE | Techfields Biochem Co. Ltd (CN) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017903-A1 | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF ARYL- AND HETEROARYLACETIC ACIDS WITH VERY FAST SKIN PENETRATION RATE | TECHFIELDS BIOCHEM CO. LTD (CN) | 2008-02-14 | — | — | WO | disclosed |
| EP-0115424-B1 | PYRROLE-2-ACETYLAMINO ACID DERIVATIVES | McNeilab, Inc. (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0115424-A1 | Pyrrole-2-acetylamino acid derivatives | McNeilab, Inc. (US) | 1984-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170209404-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885CXCL8 187/4885AKR1B1 688/4885 |
| US-20210353579-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885CXCL8 187/4885AKR1B1 688/4885 |
| US-20170209585-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885CXCL8 187/4885AKR1B1 688/4885 |
| US-20090238763-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885CXCL8 187/4885AKR1B1 688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.