Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2C | Q14957 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815189 | 0.89 | LMNA (0.36) | GRIN2CLMNARIPK1CYP2D6ALDH1A1 | |
| SCHEMBL3819392 | 0.88 | RIPK1 (0.46) | LMNAGRM5RIPK1CYP2D6ALDH1A1 | |
| SCHEMBL3810315 | 0.86 | ALDH1A1 (0.35) | GRIN2CLMNAGRM5RIPK1ALDH1A1 | |
| SCHEMBL3820038 | 0.86 | GRM5 (0.37) | LMNAGRM5RIPK1CYP2D6ALDH1A1 | |
| SCHEMBL3812861 | 0.86 | KRAS (0.40) | GRIN2CGRM5 | |
| SCHEMBL1010730 | 0.86 | GRM5 (0.52) | GRM5ALDH1A1ESR1POLBESR2 | |
| SCHEMBL3819542 | 0.85 | MTNR1B (0.43) | GRIN2CALDH1A1ESR1POLBESR2 | |
| SCHEMBL3820983 | 0.83 | TP53 (0.35) | GRIN2CGRM5CYP2D6ALDH1A1ESR1 | |
| SCHEMBL3816808 | 0.80 | MTNR1B (0.39) | GRIN2CGRM5 | |
| SCHEMBL3815380 | 0.79 | GRM5 (0.35) | GRIN2CLMNAGRM5RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |