Sugi Predict

Sugi Predict / Compounds / SCHEMBL3813374

SCHEMBL3813374

SCHEMBL3813374

CN(Cc1ccc(C(=O)N2CC3CCC(C)(C2)C3(C)C)cc1)C(=O)c1cccc(F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ HTT P42858 1/20 0.40
▸ ATM Q13315 1/20 0.38
▸ HPGD P15428 2/20 0.38
▸ LIMK2 P53671 1/20 0.38
▸ NAMPT P43490 1/20 0.38
▸ TSHR P16473 2/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ PDK1 Q15118 2/20 0.37
▸ PDK2 Q15119 2/20 0.37
▸ PDK3 Q15120 2/20 0.37
▸ PDK4 Q16654 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ HSD11B1 P28845 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3812022 0.89 HDAC1 (0.46) KMT2AMEN1ALDH1A1ATMHPGD
SCHEMBL13838903 0.87 JAK2 (0.41) KMT2AMEN1ALDH1A1HTTATM
SCHEMBL3810933 0.81 KMT2A (0.48) KMT2AMEN1ALDH1A1HTTHPGD
SCHEMBL3811439 0.79 LMNA (0.37) KMT2AALDH1A1HPGD
SCHEMBL3814369 0.79 HRH3 (0.39) KMT2AMEN1ALDH1A1HPGDGAA
SCHEMBL3811254 0.77 ALDH1A1 (0.36) KMT2AALDH1A1HPGDGAA
SCHEMBL3811818 0.77 AOC3 (0.40) KMT2AMEN1ALDH1A1HPGD
SCHEMBL3813497 0.77 SMN1; SMN2 (0.55) KMT2AMEN1ALDH1A1HTTHPGD
SCHEMBL3811384 0.76 CCR5 (0.40) KMT2AMEN1ALDH1A1HTTCYP2D6
SCHEMBL12576932 0.74 HRH3 (0.37) KMT2AALDH1A1HPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090124598-A1 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES HIGH POINT PHARMACEUTICALS, LLC 2009-05-14 — — US claimed
EP-1948190-A2 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES TRANSTECH PHARMA (US) 2008-07-30 — — EP claimed
WO-2007051810-A2 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES TRANSTECH PHARMA (US) 2007-05-10 — — WO claimed
US-20090124598-A1 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES HIGH POINT PHARMACEUTICALS, LLC 2009-05-14 — — US disclosed
US-20090124598-A1 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES HIGH POINT PHARMACEUTICALS, LLC 2009-05-14 — — US disclosed
US-20090124598-A1 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES HIGH POINT PHARMACEUTICALS, LLC 2009-05-14 — — US disclosed
EP-1948190-A2 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES TRANSTECH PHARMA (US) 2008-07-30 — — EP disclosed
WO-2007051810-A2 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES TRANSTECH PHARMA (US) 2007-05-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090124598-A1 PHARMACEUTICAL USE OF SUBSTITUTED AMIDES HSD11B1, HSD11B2, HSD3B1 KMT2A 2957/4885MEN1 2362/4885ALDH1A1 220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.