Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381812 | 0.91 | CHRM3 (0.33) | ROCK2TP53HSD11B1CHRM3CNR1 | |
| SCHEMBL381971 | 0.89 | CHRM3 (0.33) | ROCK2TP53HSD11B1CHRM3 | |
| SCHEMBL381753 | 0.88 | PKM (0.39) | TP53HSD11B1CHRM3 | |
| SCHEMBL381752 | 0.88 | PKM (0.39) | TP53HSD11B1CHRM3 | |
| SCHEMBL381541 | 0.84 | MAPT (0.34) | TP53HSD11B1 | |
| SCHEMBL381162 | 0.84 | TP53 (0.41) | TP53HSD11B1SLC6A3KMT2A | |
| SCHEMBL4028976 | 0.83 | HSD11B1 (0.40) | ROCK2TP53HSD11B1CNR1KMT2A | |
| SCHEMBL381822 | 0.82 | HSD11B1 (0.37) | ROCK2TP53HSD11B1KMT2A | |
| SCHEMBL13031209 | 0.82 | HSD11B1 (0.37) | ROCK2TP53HSD11B1KMT2A | |
| SCHEMBL381499 | 0.82 | MCHR1 (0.34) | HSD11B1CHRM3SLC6A4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |