Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 7/20 | 0.33 |
| ▸ | APOL1 | O14791 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381812 | 0.91 | CHRM3 (0.33) | CHRM3HSD11B1ROCK2TP53HDAC3 | |
| SCHEMBL381487 | 0.89 | ROCK2 (0.36) | CHRM3HSD11B1ROCK2TP53 | |
| SCHEMBL381326 | 0.86 | EPHX2 (0.40) | APOL1DPP4DPP7MAPK1TP53 | |
| SCHEMBL13031210 | 0.86 | EPHX2 (0.40) | APOL1DPP4DPP7MAPK1TP53 | |
| SCHEMBL381541 | 0.85 | MAPT (0.34) | HSD11B1MCHR1LMNATP53 | |
| SCHEMBL15204265 | 0.84 | HSD11B1 (0.42) | HSD11B1ACHE | |
| SCHEMBL381499 | 0.83 | MCHR1 (0.34) | CHRM3HSD11B1MCHR1CTSS | |
| SCHEMBL381332 | 0.83 | MCHR1 (0.34) | CHRM3HSD11B1MCHR1CTSS | |
| SCHEMBL381752 | 0.83 | PKM (0.39) | CHRM3HSD11B1LMNAMAPK1L3MBTL1 | |
| SCHEMBL381753 | 0.83 | PKM (0.39) | CHRM3HSD11B1LMNAMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |