Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819879 | 0.91 | RIPK1 (0.34) | RIPK1TRPA1LMNAKDM4EL3MBTL1 | |
| SCHEMBL2263002 | 0.84 | LMNA (0.34) | TRPA1LMNAKDM4EL3MBTL1 | |
| SCHEMBL1403700 | 0.83 | LMNA (0.39) | RIPK1LMNAKDM4EL3MBTL1 | |
| SCHEMBL27785062 | 0.83 | HRH1 (0.41) | RIPK1LMNA | |
| SCHEMBL1403779 | 0.80 | ALDH1A1 (0.38) | RIPK1LMNAKDM4E | |
| SCHEMBL1569932 | 0.79 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL27306885 | 0.78 | LMNA (0.57) | RIPK1TRPA1LMNAKDM4EL3MBTL1 | |
| SCHEMBL10706532 | 0.78 | LMNA (0.33) | LMNAKDM4EL3MBTL1 | |
| Water SCHEMBL27676524 | 0.77 | RIPK1 (0.55) | RIPK1TRPA1LMNAKDM4EL3MBTL1 | |
| SCHEMBL17510071 | 0.77 | TRPA1 (0.35) | TRPA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089373-A1 | STAT3/5 ACTIVATION INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008044667-A1 | STAT3/5 ACTIVATION INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-17 | — | — | WO | disclosed |