Sugi Predict

Sugi Predict / Compounds / SCHEMBL382162

SCHEMBL382162

SCHEMBL382162

CCOC(=O)CC(=O)c1cccc(OC)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.56
▸ KMT2A Q03164 3/20 0.56
▸ MEN1 O00255 2/20 0.56
▸ KDM4E B2RXH2 1/20 0.56
▸ CES2 O00748 1/20 0.56
▸ CES1 P23141 1/20 0.56
▸ NPC1 O15118 5/20 0.55
▸ RAB9A P51151 5/20 0.55
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ POLB P06746 1/20 0.53
▸ BLM P54132 1/20 0.53
▸ MAPT P10636 2/20 0.53
▸ TDP1 Q9NUW8 1/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ PARP1 P09874 1/20 0.53
▸ HDAC3 O15379 1/20 0.52
▸ HDAC4 P56524 1/20 0.52
▸ HDAC1 Q13547 1/20 0.52
▸ HDAC7 Q8WUI4 1/20 0.52
▸ HDAC2 Q92769 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2130116 0.87 CES2 (0.62) ALDH1A1KMT2AMEN1CES2CES1
SCHEMBL30626936 0.87 CES2 (0.62) ALDH1A1KMT2AMEN1CES2CES1
SCHEMBL30666361 0.87 ALDH1A1 (0.59) ALDH1A1CES2CES1NPC1RAB9A
SCHEMBL3161746 0.86 SMPD1 (0.65) ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL381515 0.86 ALDH1A1 (0.47) ALDH1A1KMT2AMEN1KDM4ECES2
SCHEMBL30758862 0.85 CES2 (0.69) ALDH1A1KMT2AMEN1KDM4ECES2
SCHEMBL11248287 0.85 CES2 (0.69) ALDH1A1KMT2AMEN1KDM4ECES2
SCHEMBL7028931 0.85 KMT2A (0.56) ALDH1A1KMT2AMEN1KDM4ECES2
SCHEMBL1528398 0.84 KMT2A (0.67) ALDH1A1KMT2AMEN1KDM4ENPC1
SCHEMBL2644205 0.84 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109369591-A A kind of synthetic method of diosmetin 陕西嘉禾生物科技股份有限公司 2019-02-22 — — CN claimed
WO-2025064210-A1 INHIBITORS OF BILIVERDIN REDUCTASE B (BLVRB) BLOOD CELL TECHNOLOGIES, LLC (US) 2025-03-27 — — WO disclosed
CN-119528903-A Compounds for the treatment of spinal muscular atrophy PTC医疗公司 2025-02-28 — — CN disclosed
US-20250011319-A1 SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF LOMOND THERAPEUTICS, INC. 2025-01-09 — — US disclosed
CN-108299314-B Compounds for the treatment of spinal muscular atrophy PTC医疗公司 2024-11-26 — — CN disclosed
CN-118598836-A Method for asymmetrically synthesizing chiral trans-3, 4-dihydrocoumarin derivative 中北大学 2024-09-06 — — CN disclosed
CN-118076605-A Substituted 1H-pyrazolo [4,3-c ] quinolines, methods of preparation and uses thereof 洛蒙治疗公司 2024-05-24 — — CN disclosed
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2024-02-29 — — US disclosed
WO-2024024760-A1 PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT 公益財団法人野口研究所 2024-02-01 — — WO disclosed
US-11753407-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2023-09-12 — — US disclosed
US-20050277640-A1 Pyrimidine derivatives for treatment of hyperproliferative disorders BAYER PHARMACEUTICALS CORPORATION (US) 2005-12-15 — — US disclosed
CN-1676515-A 3-acyl-pyrrolidine-2,4-diketo compound and herbicidal activity UNIV NANKAI (CN) 2005-10-05 — — CN disclosed
WO-2005035507-A2 4-AMINOPYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2005-04-21 — — WO disclosed
US-6229016-B1 PYRIDOPYRIMIDINE DERIVATIVES AS CHEMICAL INTERMEDIATES; POLYMERIZATION INHIBITION OF TUBULIN THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2001-05-08 — — US disclosed
CN-1259947-A 2-aryl-naphthyridin-4-ones as antitumor agents UNIV NORTH CAROLINA CHAPEL HILL (US) 2000-07-12 — — CN disclosed
US-6071930-A FOR INHIBITION OF MITOSIS OR TUMOR GROWTH THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2000-06-06 — — US disclosed
EP-0971921-A1 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS The University of North Carolina at Chapel Hill (US) 2000-01-19 — — EP disclosed
US-5994367-A PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-11-30 — — US disclosed
WO-1998039332-A1 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1998-09-11 — — WO disclosed
US-4042707-A ANALGESICS, NARCOTIC ANTAGONISTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-08-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 ALDH1A1 1088/4885KMT2A 1582/4885MEN1 3423/4885
US-20250011319-A1 SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF FLT3, PDXK, PHKG1 ALDH1A1 2059/4885KMT2A 863/4885MEN1 2419/4885
US-20050277640-A1 Pyrimidine derivatives for treatment of hyperproliferative disorders TYMP, DPYD, CCNA2 ALDH1A1 1122/4885KMT2A 688/4885MEN1 2266/4885
US-11753407-B2 Compounds for treating spinal muscular atrophy SMN1; SMN2, CPT1B, GYS1 ALDH1A1 1651/4885KMT2A 1623/4885MEN1 2518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.