Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 17/20 | 0.65 |
| ▸ | CA1 | P00915 | 13/20 | 0.59 |
| ▸ | CA9 | Q16790 | 12/20 | 0.59 |
| ▸ | CA12 | O43570 | 10/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.59 |
| ▸ | CA5A | P35218 | 5/20 | 0.59 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.59 |
| ▸ | CA6 | P23280 | 3/20 | 0.59 |
| ▸ | CA7 | P43166 | 3/20 | 0.59 |
| ▸ | CA3 | P07451 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CA4 | P22748 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888903 | 0.84 | CYP3A4 (0.48) | CA2CA1CA9CA12CA14 | |
| SCHEMBL15270833 | 0.82 | TSHR (0.54) | CA2CA1CA9CA12CA14 | |
| SCHEMBL176891 | 0.79 | CA2 (1.00) | CA2CA1CA9CA12CA14 | |
| SCHEMBL4718976 | 0.77 | CA2 (0.67) | CA2CA1CA9CA12CA14 | |
| SCHEMBL2206586 | 0.77 | HTT (0.62) | TSHR | |
| SCHEMBL202948 | 0.77 | CA2 (0.81) | CA2CA1CA9CA12CA14 | |
| SCHEMBL19608275 | 0.77 | CA2 (0.66) | CA2CA1CA9CA12CA14 | |
| SCHEMBL3814297 | 0.75 | CA2 (0.59) | CA2CA1CA9CA12CA14 | |
| Benzenesulfonamide SCHEMBL2473936 | 0.74 | CA2 (0.76) | CA2CA1CA9CA12CA14 | |
| Carzenide SCHEMBL312419 | 0.74 | CA2 (1.00) | CA2CA1CA9CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
| EP-1348706-B1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2009-08-19 | — | — | EP | disclosed |
| US-7067537-B2 | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-27 | — | — | US | disclosed |
| CN-1173959-C | 8,8A-dihydro-indeno [1,2-D] thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, a method for production thereof and use thereof as a medicament | ���ĵ�˹ҩ��¹�����˾ | 2004-11-03 | — | — | CN | disclosed |
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20040072876-A1 | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-15 | — | — | US | disclosed |
| EP-1348706-A1 | SUBSTITUTED THIAZOLE DERIVATIVES BEARING 3-PYRIDYL GROUPS, PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2003-10-01 | — | — | EP | disclosed |
| EP-1261593-B1 | 8,8A-DIHYDRO-INDENO 1,2-D]THIAZOLE DERIVATIVES WITH A SULPHONAMIDO OR SULPHONO SUBSTITUENT IN THE 2 POSITION, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF AS A MEDICAMENT | AVENTIS PHARMA GMBH (DE) | 2003-08-27 | — | — | EP | disclosed |
| CN-1406234-A | 8,8A-dihydro-indeno [1,2-D] thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, a method for production thereof and use thereof as a medicament | AVENTIS PHARMA GMBH (DE) | 2003-03-26 | — | — | CN | disclosed |
| EP-1261593-A1 | 8,8A-DIHYDRO-INDENO 1,2-D]THIAZOLE DERIVATIVES WITH A SULPHONAMIDO OR SULPHONO SUBSTITUENT IN THE 2 POSITION, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF AS A MEDICAMENT | Aventis Pharma Deutschland GmbH (DE) | 2002-12-04 | — | — | EP | disclosed |
| US-6444669-B1 | SUCH AS 4-CHLORO-N-(4-(6-CHLORO-3A-HYDROXY-8,8A-DIHYDRO-3AH-INDENO(1,2-D)THIAZOL-2 -YL)-PHENYL)BENZENE-SULFONAMIDE; FOR THE PROPHYLAXIS OR TREATMENT OF OBESITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-09-03 | — | — | US | disclosed |
| US-20020103231-A1 | 8,8a-dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-08-01 | — | — | US | disclosed |
| US-6352987-B2 | ANORECTIC AND ANTIDIABETIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-03-05 | — | — | US | disclosed |
| US-20010039278-A1 | 8,8a-dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2001-11-08 | — | — | US | disclosed |
| WO-2001062747-A1 | 8,8A-DIHYDRO-INDENO[1,2-D]THIAZOLE DERIVATIVES WITH A SULPHONAMIDO OR SULPHONO SUBSTITUENT IN THE 2 POSITION, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF AS A MEDICAMENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-08-30 | — | — | WO | disclosed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072876-A1 | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof | CYP17A1, CYP21A2, HSD17B1 | CA2 393/4885CA1 466/4885CA9 204/4885 |
| US-20020103231-A1 | 8,8a-dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments | SULT1E1, SULT2A1, SULT1A1 | CA2 357/4885CA1 442/4885CA9 1495/4885 |
| US-20010039278-A1 | 8,8a-dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments | SULT1E1, SULT2A1, SULT1A1 | CA2 357/4885CA1 442/4885CA9 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.