Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824877 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL6516189 | 0.99 | ALDH1A1 (0.49) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| Amidate SCHEMBL30937751 | 0.83 | GABRA1 (0.74) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL15988340 | 0.82 | GABRA1 (0.48) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL28191535 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL6518667 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL28188102 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL24283708 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL24283843 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TDP1GABRA1LMNACYP1A2 | |
| SCHEMBL21298732 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TDP1GABRA1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184512-B1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | MASSACHUSETTS GEN HOSPITAL (US) | 2020-12-23 | — | — | EP | disclosed |
| US-10154991-B2 | Anesthetic compounds and related methods of use | ANNOVATION BIOPHARMA, INC. (US) | 2018-12-18 | — | — | US | disclosed |
| US-20180098968-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2018-04-12 | — | — | US | disclosed |
| US-9820971-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2017-11-21 | — | — | US | disclosed |
| US-20170273951-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2017-09-28 | — | — | US | disclosed |
| EP-3184512-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | The General Hospital Corporation (US) | 2017-06-28 | — | — | EP | disclosed |
| US-9522136-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2016-12-20 | — | — | US | disclosed |
| EP-2802325-B1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | GEN HOSPITAL CORP (US) | 2016-11-30 | — | — | EP | disclosed |
| US-20150328189-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | ANNOVATION BIOPHARMA, LLC. (US) | 2015-11-19 | — | — | US | disclosed |
| US-9156825-B2 | Anesthetic compounds and related methods of use | THE GENERAL HOSPITAL CORPORATION (US) | 2015-10-13 | — | — | US | disclosed |
| US-20150203476-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION | 2015-07-23 | — | — | US | disclosed |
| EP-2802325-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | The General Hospital Corporation (US) | 2014-11-19 | — | — | EP | disclosed |
| WO-2013106717-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | THE GENERAL HOSPITAL CORPORATION (US) | 2013-07-18 | — | — | WO | disclosed |
| US-20090156562-A1 | NOVEL COLORED SOLUTIONS OF INJECTABLE DRUGS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | WINCH PETER D | 2009-06-18 | — | — | US | disclosed |
| EP-1951248-A2 | NOVEL COLORED SOLUTIONS OF INJECTABLE DRUGS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | Winch, Peter D. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007059019-A2 | NOVEL COLORED SOLUTIONS OF INJECTABLE DRUGS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | WINCH PETER D (US) | 2007-05-24 | — | — | WO | disclosed |
| CN-1138540-C | Antalgic and sedative oral etomidate preparation | 中国人民解放军第四军医大学 | 2004-02-18 | — | — | CN | disclosed |
| CN-1308938-A | Antalgic and sedative oral etomidate preparation | MILITARY MEDICAL UNIV NO 4 OF (CN) | 2001-08-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150328189-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | ALDH1A1 77/4885TDP1 2811/4885GABRA1 62/4885 |
| US-20170273951-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | ALDH1A1 77/4885TDP1 2811/4885GABRA1 62/4885 |
| US-20150203476-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | ALDH1A1 77/4885TDP1 2811/4885GABRA1 62/4885 |
| US-10154991-B2 | Anesthetic compounds and related methods of use | OPRM1, OPRK1, OPRL1 | ALDH1A1 77/4885TDP1 2811/4885GABRA1 62/4885 |
| US-20090156562-A1 | NOVEL COLORED SOLUTIONS OF INJECTABLE DRUGS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | CYP3A5, IK, ACHE | ALDH1A1 640/4885TDP1 4115/4885GABRA1 351/4885 |
| US-20180098968-A1 | ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE | OPRM1, OPRK1, OPRL1 | ALDH1A1 77/4885TDP1 2811/4885GABRA1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.