Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890948 | 0.77 | ACSS2 (0.48) | TLR7APEX1BRD4ACSS2 | |
| SCHEMBL1889761 | 0.74 | KDM4E (0.44) | TLR7PPARGPPARA | |
| SCHEMBL1585672 | 0.72 | BRD4 (0.54) | TLR7BRD4P2RX7BRD9 | |
| SCHEMBL1886847 | 0.71 | BRD4 (0.38) | BRD4 | |
| SCHEMBL1885760 | 0.71 | DCTPP1 (0.42) | PPARGPPARA | |
| SCHEMBL31047346 | 0.69 | OPRM1 (0.41) | BRD4P2RX7 | |
| SCHEMBL7712674 | 0.69 | P2RX7 (0.48) | BRD4PPARGP2RX7CNR2BRD9 | |
| SCHEMBL1882734 | 0.69 | ACSS2 (0.46) | TLR7BRD4ACSS2 | |
| SCHEMBL5757395 | 0.68 | POLB (0.47) | BRD4CNR2BRD9 | |
| SCHEMBL31613842 | 0.68 | OPRM1 (0.39) | BRD4P2RX7BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814865-A4 | BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | WYETH CORP (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-1814865-A2 | BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | Athersys, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006034418-A2 | BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF | ATHERSYS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |