Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 10/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382455 | 0.87 | DRD2 (0.42) | DRD2DRD3KDM4EKMT2A | |
| SCHEMBL7473696 | 0.87 | OPRK1 (0.42) | OPRK1ALDH1A1KDM4E | |
| SCHEMBL382924 | 0.81 | ALDH1A1 (0.48) | MAPTALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL6500965 | 0.81 | OPRK1 (0.51) | OPRK1DRD2DRD3MAPTALDH1A1 | |
| SCHEMBL7473689 | 0.80 | ALDH1A1 (0.39) | OPRK1MAPTHRH3ALDH1A1KDM4E | |
| SCHEMBL382363 | 0.80 | ALDH1A1 (0.46) | OPRK1MAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL6504216 | 0.79 | DRD2 (0.43) | OPRK1DRD2DRD3MAPTALDH1A1 | |
| SCHEMBL6507428 | 0.79 | KDM4E (0.46) | DRD2DRD3MAPTHRH3ALDH1A1 | |
| SCHEMBL382395 | 0.78 | ALDH1A1 (0.48) | OPRK1MAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL381825 | 0.78 | EPHX2 (0.36) | DRD2DRD3ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |