Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828503 | 0.87 | IKBKB (0.45) | MAPK14BCL2A1VNN1PDK1 | |
| SCHEMBL3823686 | 0.86 | BCL2A1 (0.47) | MAPK14BCL2A1VNN1HCAR3PDK1 | |
| SCHEMBL3829758 | 0.84 | BCL2A1 (0.45) | MAPK14BCL2A1VNN1PDK1PDK2 | |
| SCHEMBL3822748 | 0.82 | BCL2A1 (0.52) | MAPK14BCL2A1KCNQ3KCNQ2VNN1 | |
| SCHEMBL4735448 | 0.81 | MAPK14 (0.55) | MAPK14HCAR3PDK1 | |
| SCHEMBL3058152 | 0.80 | CYP11B1 (0.43) | MAPK14KCNQ3KCNQ2VNN1PRKAA2 | |
| SCHEMBL3828507 | 0.80 | PDK1 (0.45) | MAPK14BCL2A1VNN1PDK1PDK2 | |
| SCHEMBL3830084 | 0.79 | PDK1 (0.49) | MAPK14BCL2A1VNN1PDK1PDK2 | |
| SCHEMBL3824490 | 0.79 | MCHR1 (0.47) | PRKAA2KCNH2 | |
| SCHEMBL4737583 | 0.79 | GAA (0.46) | MAPK14PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |