Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826441 | 0.87 | MAPK14 (0.49) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3829758 | 0.85 | BCL2A1 (0.45) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3823686 | 0.84 | BCL2A1 (0.47) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3058766 | 0.81 | CRHR1 (0.45) | IKBKBCRHR1VNN1GABRA5ACHE | |
| SCHEMBL3822748 | 0.80 | BCL2A1 (0.52) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3828507 | 0.78 | PDK1 (0.45) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3830084 | 0.77 | PDK1 (0.49) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3829755 | 0.76 | PDK1 (0.48) | BCL2A1VNN1PDK1MAPK14 | |
| SCHEMBL3831162 | 0.75 | RAB9A (0.53) | BCL2A1PDK1MAPK14 | |
| SCHEMBL3821700 | 0.75 | CNR2 (0.49) | BCL2A1VNN1PDK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |