Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784635 | 0.86 | MEN1 (0.42) | P2RX7HTR2BLTB4RLTB4R2DRD2 | |
| SCHEMBL5801145 | 0.76 | LPL (0.44) | P2RX7 | |
| SCHEMBL24915634 | 0.76 | LTB4R (0.45) | P2RX7LTB4RLTB4R2DRD2DRD3 | |
| SCHEMBL506553 | 0.76 | PDPK1 (0.46) | LTB4RLTB4R2HTR2A | |
| Hydrochloric Acid SCHEMBL30799506 | 0.74 | PDPK1 (0.44) | HTR2A | |
| SCHEMBL31704396 | 0.74 | MAPK1 (0.47) | P2RX7HTR2BLTB4RLTB4R2MAPK1 | |
| SCHEMBL6369306 | 0.73 | ADRA2A (0.58) | P2RX7LTB4RLTB4R2 | |
| SCHEMBL5019356 | 0.72 | HTR2A (0.48) | HTR2BLTB4RLTB4R2HTR2A | |
| SCHEMBL5541762 | 0.71 | LTB4R (0.47) | HTR2BLTB4RLTB4R2DRD2DRD3 | |
| SCHEMBL28731735 | 0.71 | HDAC1 (0.42) | P2RX7HTR2BLTB4RLTB4R2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091933-A1 | DIHYDROBENZOFURANYL DERIVATIVES AND METHODS OF THEIR USE | Wyeth (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008073943-A1 | DIHYDROBENZOFURANYL DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |