Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065671 | 0.81 | KCNQ4 (0.41) | HTR2ACHRM2CHRM1CHRM3LMNA | |
| SCHEMBL4237307 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL19868563 | 0.78 | LOXL2 (0.51) | ALDH1A1KDM4EMEN1KMT2AMEP1B | |
| SCHEMBL28986105 | 0.76 | NPC1 (0.61) | ALDH1A1TSHRMEN1KMT2ANPC1 | |
| SCHEMBL4089396 | 0.76 | CHRM2 (0.52) | ALDH1A1MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL6831433 | 0.76 | LTB4R2 (0.54) | MEN1KMT2AMAPK14RAB9ALTB4R2 | |
| SCHEMBL4737056 | 0.76 | CHRM2 (0.47) | ALDH1A1KDM4ETSHRMAPK14CHRM2 | |
| SCHEMBL1335750 | 0.75 | MAPK14 (0.54) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL6827496 | 0.74 | RAB9A (0.53) | ALDH1A1MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL14809509 | 0.74 | BCL2A1 (0.51) | ALDH1A1KDM4ETSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |