Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738206 | 0.86 | CHRM2 (0.46) | CHRM2CHRM1CHRM3MAPK14KDM4E | |
| SCHEMBL3058213 | 0.84 | CHRM1 (0.44) | CHRM2CHRM1CHRM3KDM4EACHE | |
| SCHEMBL13090649 | 0.78 | KDM4E (0.45) | CHRM2CHRM1CHRM3KDM4EALDH1A1 | |
| SCHEMBL3830101 | 0.76 | ALDH1A1 (0.44) | CHRM2CHRM1CHRM3MAPK14KDM4E | |
| SCHEMBL19868563 | 0.73 | LOXL2 (0.51) | MAPTKDM4EALDH1A1MEP1B | |
| SCHEMBL3824005 | 0.71 | L3MBTL1 (0.47) | MAPTKDM4EALDH1A1 | |
| SCHEMBL3058780 | 0.71 | CHRM1 (0.44) | CHRM2CHRM1CHRM3MAPTALDH1A1 | |
| SCHEMBL4237307 | 0.71 | ALDH1A1 (0.54) | MAPK14KDM4EALDH1A1TSHR | |
| SCHEMBL28986105 | 0.70 | NPC1 (0.61) | ALDH1A1TSHRPDK1 | |
| SCHEMBL6831433 | 0.69 | LTB4R2 (0.54) | MAPK14PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |