Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31533293 | 0.84 | KMT2A (0.37) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL31336207 | 0.82 | ABCG2 (0.37) | MAOAKDM4EALDH1A1NPC1LMNA | |
| SCHEMBL5026754 | 0.75 | MAOA (0.74) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL10431693 | 0.72 | ADRB2 (0.48) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL6002951 | 0.72 | MAOA (0.50) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL17076945 | 0.72 | PGR (0.39) | MAOAKDM4EALDH1A1NPC1LMNA | |
| SCHEMBL13990695 | 0.71 | CYP2A6 (0.57) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL1926672 | 0.71 | MAOA (0.47) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL2685825 | 0.70 | MAOA (0.49) | MAOAADRB2KDM4EALDH1A1NPC1 | |
| SCHEMBL15473271 | 0.69 | CYP2A6 (0.59) | MAOAADRB2KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755585-A4 | TRANSTHYRETIN STABILIZATION | SCRIPPS RESEARCH INST (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1755585-A1 | TRANSTHYRETIN STABILIZATION | The Scripps Research Institute (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005112913-A1 | TRANSTHYRETIN STABILIZATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050261365-A1 | Transthyretin stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261365-A1 | Transthyretin stabilization | TTR, TTPA, ALB | MAOA 1813/4885ADRB2 4226/4885KDM4E 3239/4885 |
| US-20080319175-A1 | Transthyretin Stabilization | TTR, TTPA, ALB | MAOA 1813/4885ADRB2 4226/4885KDM4E 3239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.