Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.52 |
| ▸ | DRD4 | P21917 | 6/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 5/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823664 | 0.94 | MAPT (0.53) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3829698 | 0.91 | DRD2 (0.54) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3824735 | 0.89 | HTR1A (0.52) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3825171 | 0.88 | RAB9A (0.53) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3827024 | 0.88 | RAB9A (0.52) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| Hydrochloric Acid SCHEMBL3822406 | 0.87 | RAB9A (0.52) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3831162 | 0.87 | RAB9A (0.53) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL8182148 | 0.85 | DRD4 (0.47) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3830147 | 0.85 | SIGMAR1 (0.50) | DRD2DRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL3826319 | 0.85 | DRD4 (0.47) | DRD2DRD4TMEM97SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |