Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 4/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.37 |
| ▸ | PYGL | P06737 | 2/20 | 0.36 |
| ▸ | PYGB | P11216 | 2/20 | 0.35 |
| ▸ | PYGM | P11217 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5688958 | 0.76 | SLC6A2 (0.43) | SLC5A2 | |
| SCHEMBL3839216 | 0.75 | LGALS9 (0.38) | PYGB | |
| SCHEMBL6009962 | 0.71 | SLC5A1 (0.39) | SLC5A2SLC5A1PYGLPYGB | |
| SCHEMBL12899843 | 0.69 | CYP3A4 (0.36) | SLC5A2SLC5A1 | |
| SCHEMBL12930026 | 0.69 | CYP3A4 (0.36) | SLC5A2SLC5A1 | |
| SCHEMBL14939308 | 0.69 | SLC5A2 (0.38) | SLC5A2PYGLPYGBPYGM | |
| SCHEMBL10417574 | 0.69 | SLC5A2 (0.38) | SLC5A2PYGLPYGBPYGM | |
| SCHEMBL29752599 | 0.69 | SLC5A2 (0.38) | SLC5A2PYGLPYGBPYGM | |
| SCHEMBL4622083 | 0.69 | SLC5A2 (0.38) | SLC5A2PYGLPYGBPYGM | |
| SCHEMBL12762745 | 0.69 | SLC5A2 (0.38) | SLC5A2PYGLPYGBPYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222927-B1 | Pharmaceutical compositions having appetite suppressant activity | CSIR (ZA) | 2013-11-20 | — | — | EP | disclosed |
| EP-1213020-B1 | Compounds and pharmaceutical compositions having appetite suppressant activity | CSIR (ZA) | 2009-02-11 | — | — | EP | disclosed |
| US-7166611-B2 | Plant extract comprising steroidal glycosides from the genus Trichocaulon or Hoodia produced by solvent extraction | CSIR (ZA) | 2007-01-23 | — | — | US | disclosed |
| US-20060205931-A1 | Pharmaceutical compositions having appetite suppressant activity | CSIR | 2006-09-14 | — | — | US | disclosed |
| EP-1598054-A2 | Method of suppressing appetite | CSIR (ZA) | 2005-11-23 | — | — | EP | disclosed |
| US-20040234634-A1 | Pharmaceutical compositions having appetite suppressant activity | CSIR | 2004-11-25 | — | — | US | disclosed |
| US-20040228935-A1 | Pharmaceutical compositions having appetite suppressant activity | CSIR | 2004-11-18 | — | — | US | disclosed |
| EP-1438965-A1 | Use of extracts from Hoodia gordonii and Hoodia lugardii for the preparation of a medicament for use in the suppression of appetite | CSIR (ZA) | 2004-07-21 | — | — | EP | disclosed |
| US-20030086984-A1 | Pharmaceutical compositions having appetite suppressant activity | CSIR | 2003-05-08 | — | — | US | disclosed |
| US-20020168427-A1 | Pharmaceutical compositions having appetite suppressant activity | CSIR | 2002-11-14 | — | — | US | disclosed |
| EP-1222927-A2 | Pharmaceutical compositions having appetite suppressant activity | CSIR (ZA) | 2002-07-17 | — | — | EP | disclosed |
| EP-1213020-A2 | Pharmaceutical compositions having appetite suppressant activity | CSIR (ZA) | 2002-06-12 | — | — | EP | disclosed |
| US-6376657-B1 | STEROID TRISACCHARIDE EXTRACT OBTAINABLE FROM A PLANT OF THE GENUS TRICHOCAULON OR HOODIA | CSIR (ZA) | 2002-04-23 | — | — | US | disclosed |
| EP-0973534-A1 | PHARMACEUTICAL COMPOSITIONS HAVING APPETITE SUPPRESSANT ACTIVITY | CSIR (ZA) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998046243-A2 | PHARMACEUTICAL COMPOSITIONS HAVING APPETITE SUPPRESSANT ACTIVITY | CSIR (ZA) | 1998-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040234634-A1 | Pharmaceutical compositions having appetite suppressant activity | GPR119, TPH1, TRHR | SLC5A2 1003/4885SLC5A1 513/4885PYGL 2604/4885 |
| US-20020168427-A1 | Pharmaceutical compositions having appetite suppressant activity | GPR119, TPH1, TRHDE | SLC5A2 1019/4885SLC5A1 538/4885PYGL 2640/4885 |
| US-20030086984-A1 | Pharmaceutical compositions having appetite suppressant activity | TPH1, TRHDE, TRHR | SLC5A2 767/4885SLC5A1 439/4885PYGL 2553/4885 |
| US-20040228935-A1 | Pharmaceutical compositions having appetite suppressant activity | GPR119, TPH1, TRHDE | SLC5A2 986/4885SLC5A1 502/4885PYGL 2633/4885 |
| US-20060205931-A1 | Pharmaceutical compositions having appetite suppressant activity | GPR119, TPH1, TRHDE | SLC5A2 1019/4885SLC5A1 538/4885PYGL 2640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.