Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587352 | 0.72 | HTR2A (0.36) | OPRL1 | |
| SCHEMBL12206861 | 0.70 | OPRL1 (0.37) | OPRL1KCNH2OPRD1 | |
| SCHEMBL19043677 | 0.68 | OPRL1 (0.40) | OPRL1KCNH2OPRD1 | |
| SCHEMBL22275571 | 0.68 | OPRL1 (0.33) | OPRL1KCNH2 | |
| SCHEMBL20851235 | 0.68 | OPRL1 (0.33) | OPRL1KCNH2 | |
| SCHEMBL21555729 | 0.67 | ANPEP (0.40) | OPRL1KCNH2OPRD1 | |
| Hydrochloric Acid SCHEMBL17768575 | 0.66 | ANPEP (0.42) | OPRL1KCNH2OPRD1 | |
| SCHEMBL12801168 | 0.66 | OPRL1 (0.43) | OPRL1KCNH2 | |
| SCHEMBL2878241 | 0.65 | OPRL1 (0.40) | OPRL1KCNH2 | |
| SCHEMBL17529942 | 0.65 | OPRL1 (0.32) | OPRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648893-B1 | NICOTINE ADDICTION REDUCING HETEROARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PROD INC (US) | 2009-09-23 | — | — | EP | disclosed |
| EP-1648893-B1 | NICOTINE ADDICTION REDUCING HETEROARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PROD INC (US) | 2009-09-23 | — | — | EP | disclosed |
| US-7494992-B2 | Antiparasitic terpene alkaloids | PFIZER INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-7456177-B2 | Heteroaryl fused azapolycyclic compounds which bind to neuronal nicotinic acetylcholine specific receptor sites, and which are useful in modulating cholinergic function, for for reducing nicotine addiction or aiding in the cessation or lessening of tobacco use in a mammal, therapy | PFIZER INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | PFIZER PRODUCTS INC | 2007-08-09 | — | — | US | disclosed |
| EP-1597264-A2 | ANTIPARASITIC TERPENE ALKALOIDS | Pfizer Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| US-20050020830-A1 | Heteroaryl fused azapolycyclic compounds which bind to neuronal nicotinic acetylcholine specific receptor sites, and which are useful in modulating cholinergic function, for for reducing nicotine addiction or aiding in the cessation or lessening of tobacco use in a mammal, therapy | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
| WO-2004072086-A2 | ANTIPARASITIC TERPENE ALKALOIDS | PFIZER LIMITED (GB) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020830-A1 | Heteroaryl fused azapolycyclic compounds which bind to neuronal nicotinic acetylcholine specific receptor sites, and which are useful in modulating cholinergic function, for for reducing nicotine addiction or aiding in the cessation or lessening of tobacco use in a mammal, therapy | CHRNA2, CHRNA3, CHRNB2 | OPRL1 31/4885KCNH2 249/4885OPRD1 36/4885 |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | CYP51A1, DHPS, CYP8B1 | OPRL1 1295/4885KCNH2 1124/4885OPRD1 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.