Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836802 | 0.84 | PTGES (0.50) | ASIC3PTGESFFAR1 | |
| SCHEMBL2754684 | 0.81 | ASIC3 (0.45) | ASIC3ACACBCYP1A2FFAR1SIGMAR1 | |
| SCHEMBL236242 | 0.81 | ASIC3 (0.53) | ASIC3ACACBCYP1A2SIGMAR1 | |
| SCHEMBL3859050 | 0.80 | CA12 (0.47) | PTGESFFAR1 | |
| SCHEMBL9742625 | 0.80 | ASIC3 (0.53) | ASIC3ACACBCYP1A2CYP2A6FFAR1 | |
| SCHEMBL3837565 | 0.79 | PTGES (0.46) | ASIC3PTGESFFAR1CTSSCTSK | |
| SCHEMBL9742914 | 0.77 | ASIC3 (0.50) | ASIC3ACACBCYP1A2CYP2A6 | |
| SCHEMBL3841194 | 0.77 | FFAR1 (0.44) | CYP1A2PTGESFFAR1SIGMAR1 | |
| SCHEMBL140016 | 0.77 | CYP1A2 (0.68) | CYP1A2CYP2A6BCHESIGMAR1 | |
| SCHEMBL5573799 | 0.76 | ASIC3 (0.53) | ASIC3ACACBCYP1A2CYP2A6CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |