Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836802 | 0.87 | PTGES (0.50) | FFAR1KCNH2PTGES | |
| SCHEMBL16631499 | 0.86 | CA12 (0.50) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL233927 | 0.82 | CA12 (0.48) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL3859573 | 0.81 | PTGES (0.44) | FFAR1PTGESGRM5 | |
| SCHEMBL9742359 | 0.81 | ASIC3 (0.49) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL3859036 | 0.81 | FFAR1 (0.47) | FFAR1PTGESGRM5 | |
| SCHEMBL9328210 | 0.81 | FFAR1 (0.59) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL9349697 | 0.81 | FFAR1 (0.59) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL16631365 | 0.81 | CA12 (0.47) | CA12CA1CA2CA9FFAR1 | |
| SCHEMBL3864253 | 0.80 | ASIC3 (0.47) | FFAR1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |